ID   Y479_MYCTU              Reviewed;         348 AA.
AC   P9WKV7; L0T6L4; P64699; Q11145;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Uncharacterized protein Rv0479c;
GN   OrderedLocusNames=Rv0479c; ORFNames=MTCY20G9.05c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP43213.1; -; Genomic_DNA.
DR   PIR; B70743; B70743.
DR   RefSeq; NP_214993.1; NC_000962.3.
DR   RefSeq; WP_003898475.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WKV7; -.
DR   SMR; P9WKV7; -.
DR   STRING; 83332.Rv0479c; -.
DR   PaxDb; P9WKV7; -.
DR   DNASU; 885535; -.
DR   GeneID; 885535; -.
DR   KEGG; mtu:Rv0479c; -.
DR   TubercuList; Rv0479c; -.
DR   eggNOG; ENOG5032ZJ9; Bacteria.
DR   OMA; HFSTRNA; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR021373; DUF2993.
DR   Pfam; PF11209; LmeA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..348
FT                   /note="Uncharacterized protein Rv0479c"
FT                   /id="PRO_0000103681"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   348 AA;  37048 MW;  9EBB7A8CF9E176C1 CRC64;
     MTNPQGPPND PSPWARPGDQ GPLARPPASS EASTGRLRPG EPAGHIQEPV SPPTQPEQQP
     QTEHLAASHA HTRRSGRQAA HQAWDPTGLL AAQEEEPAAV KTKRRARRDP LTVFLVLIIV
     FSLVLAGLIG GELYARHVAN SKVAQAVACV VKDQATASFG VAPLLLWQVA TRHFTNISVE
     TAGNQIRDAK GMQIKLTIQN VRLKNTPNSR GTIGALDATI TWSSEGIKES VQNAIPILGA
     FVTSSVVTHP ADGTVELKGL LNNITAKPIV AGKGLELQII NFNTLGFSLP KETVQSTLNE
     FTSSLTKNYP LGIHADSVQV TSTGVVSRFS TRDAAIPTGI QNPCFSHI