Y4821_DICDI
ID Y4821_DICDI Reviewed; 854 AA.
AC Q555U5; Q86J08;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0274821;
GN ORFNames=DDB_G0274821;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AAFI02000012; EAL70303.1; -; Genomic_DNA.
DR RefSeq; XP_643965.1; XM_638873.1.
DR AlphaFoldDB; Q555U5; -.
DR SMR; Q555U5; -.
DR STRING; 44689.DDB0230007; -.
DR PaxDb; Q555U5; -.
DR EnsemblProtists; EAL70303; EAL70303; DDB_G0274821.
DR GeneID; 8619392; -.
DR KEGG; ddi:DDB_G0274821; -.
DR dictyBase; DDB_G0274821; -.
DR eggNOG; KOG0597; Eukaryota.
DR HOGENOM; CLU_334464_0_0_1; -.
DR InParanoid; Q555U5; -.
DR OMA; QIMITSR; -.
DR PRO; PR:Q555U5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045906; ULK4.
DR PANTHER; PTHR46240; PTHR46240; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..854
FT /note="Probable inactive serine/threonine-protein kinase
FT DDB_G0274821"
FT /id="PRO_0000362056"
FT TRANSMEM 770..792
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..266
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 116..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 283
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 325
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 365
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 414
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 541
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 620
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 757
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 854 AA; 97923 MW; FA494AC50DF1986B CRC64;
MPIKESFKRI KSDHQNQNQD QINYVDENVK ENLSTYYLVK RISFEYSFKE FLNSDQYLSI
DTSIIFSKNI MNALYYLHSN NIIYADLKPS NILIDSKGIF KLNSINNSIL IENNNNNNNN
NNNNNNNNNN NNNNNQQIMI TSRQQIFNLY NNNIDNDNNN NINESIYYLS PEVLKGYTYS
FSSDIWSFGV LLFKCITGYY PFYSNDATKL IESIIYDNYL DPIIRLPSDN NDLIQQQHFN
DLISKILEKN PQKRITWPKL FIHPFFKNQQ TQQVNEIINK SSNTTLQLLN KSSSSSSSSS
SSSSSSSSSS SSSSLSFQQQ QQPNNISSPN LENQVIRLNK VKIPPLNISQ TNSLNDFSNL
IENNNFTRLI SEFDHSIDFE ASPIISPNRP SSPPLSSLSS CSSSSSSSVP IIFNKTIKDL
QLLINNNNNN NNNNNNNNNN NNNNNNNNNY QEIIEYFNFI SKFIKTKTTI ITKLTLLNYL
IDLLLLSNNQ YSSIIEKLLI IINEHTILIK QLVQQIKISN DTIIKVKIIH LLGIIIGKSN
NLSINSKDSI IQLLEYLNNE ISSFNNNNNI QLSLKRKLVS TFGEILFYFS TLDEITLSTK
WGILSLEKYI NTLLNLFLIN DSSSPSSSPP PSSSSSSSSP SSPSSTSPSL LSSIPNPSLF
PQISLSSIIT TNKAIDKTIL LYLIKTFDNL LITRPIYIKY FSIKSKQLLN QFLKYIKDDN
NLEDELNNNI KISSSSAFYR IIKQQPILSL SLIDNCNESV MINMIDLNQH WRVQISFLNI
LFILITINNN FIDDNNNINN INNNNNEFIK KFLEKLYNHY INQKNQINPI VFKKSFIFYS
ILKDFNNNNF IKIN
