ID   Y4822_MYCSK             Reviewed;         314 AA.
AC   A1UMF4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase Mkms_4822;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Mkms_4822;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; CP000518; ABL94012.1; -; Genomic_DNA.
DR   RefSeq; WP_011562113.1; NC_008705.1.
DR   AlphaFoldDB; A1UMF4; -.
DR   SMR; A1UMF4; -.
DR   STRING; 189918.Mkms_4822; -.
DR   EnsemblBacteria; ABL94012; ABL94012; Mkms_4822.
DR   KEGG; mkm:Mkms_4822; -.
DR   HOGENOM; CLU_021322_0_0_11; -.
DR   OMA; QVPPYEY; -.
DR   OrthoDB; 1422015at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..314
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase
FT                   Mkms_4822"
FT                   /id="PRO_0000379579"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         266
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         286
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         295
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  32668 MW;  0AE4613A3CFA63C3 CRC64;
     MAGNSKRRGA VRKAGTKKGP TVGSGGVRRR GLEGRGATPP AHQRPNHPAA KRAAKAAKQQ
     QRRPARKTDE TELVLGRNPV VECLRAEVPA TALYVAMGTE ADERVTEAVQ IAADNGISIL
     EVPRSDLDRM SNNALHQGLG LQVPPYDYAH PDDLLATAKA DGAPALLVAL DNISDPRNLG
     AIVRSVAAFG GHGVLIPQRR SASVTAVAWR TSAGAAARLP VARATNLNRT LKSWADGGLQ
     VVGLDADGDT TLDELDGTGP VVVVVGSEGK GLSRLVRENC DAVVSIPMAG PTESLNASVA
     AGVVLAEIAR QRRS