ID   Y484_MYCTO              Reviewed;         251 AA.
AC   P9WGR4; L0T6M0; Q11150;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase MT0502;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT0502;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44725.1; -; Genomic_DNA.
DR   PIR; G70743; G70743.
DR   RefSeq; WP_003900154.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGR4; -.
DR   SMR; P9WGR4; -.
DR   EnsemblBacteria; AAK44725; AAK44725; MT0502.
DR   KEGG; mtc:MT0502; -.
DR   PATRIC; fig|83331.31.peg.532; -.
DR   HOGENOM; CLU_010194_2_10_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="Uncharacterized oxidoreductase MT0502"
FT                   /id="PRO_0000428316"
FT   ACT_SITE        149
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         12..36
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         136
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  26416 MW;  6F3956B95DB92BA2 CRC64;
     MTTIGTRKRV AVVTGASSGI GEATARTLAA QGFHVVAVAR RADRITALAN QIGGTAIVAD
     VTDDAAVEAL ARALSRVDVL VNNAGGAKGL QFVADADLEH WRWMWDTNVL GTLRVTRALL
     PKLIDSGDGL IVTVTSIAAI EVYDGGAGYT AAKHAQGALH RTLRGELLGK PVRLTEIAPG
     AVETEFSLVR FDGDQQRADA VYAGMTPLVA ADVAEVIGFV ATRPSHVNLD QIVIRPRDQA
     SASRRATHPV R