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Y484_MYCTU
ID   Y484_MYCTU              Reviewed;         251 AA.
AC   P9WGR5; L0T6M0; Q11150;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized oxidoreductase Rv0484c;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0484c; ORFNames=MTCY20G9.10c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43218.1; -; Genomic_DNA.
DR   PIR; G70743; G70743.
DR   RefSeq; NP_214998.1; NC_000962.3.
DR   RefSeq; WP_003900154.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WGR5; -.
DR   SMR; P9WGR5; -.
DR   STRING; 83332.Rv0484c; -.
DR   PaxDb; P9WGR5; -.
DR   DNASU; 887158; -.
DR   GeneID; 887158; -.
DR   KEGG; mtu:Rv0484c; -.
DR   TubercuList; Rv0484c; -.
DR   eggNOG; COG4221; Bacteria.
DR   OMA; WRWMWET; -.
DR   PhylomeDB; P9WGR5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..251
FT                   /note="Uncharacterized oxidoreductase Rv0484c"
FT                   /id="PRO_0000054863"
FT   ACT_SITE        149
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         12..36
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         136
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  26416 MW;  6F3956B95DB92BA2 CRC64;
     MTTIGTRKRV AVVTGASSGI GEATARTLAA QGFHVVAVAR RADRITALAN QIGGTAIVAD
     VTDDAAVEAL ARALSRVDVL VNNAGGAKGL QFVADADLEH WRWMWDTNVL GTLRVTRALL
     PKLIDSGDGL IVTVTSIAAI EVYDGGAGYT AAKHAQGALH RTLRGELLGK PVRLTEIAPG
     AVETEFSLVR FDGDQQRADA VYAGMTPLVA ADVAEVIGFV ATRPSHVNLD QIVIRPRDQA
     SASRRATHPV R
 
 
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