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Y485_MYCTO
ID   Y485_MYCTO              Reviewed;         438 AA.
AC   P9WKV0; L0T5I1; P64705; Q11151;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Transcriptional regulator MT0503 {ECO:0000250|UniProtKB:P9WKV1};
GN   OrderedLocusNames=MT0503;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Positively regulates the expression of PE13 and PPE18.
CC       {ECO:0000250|UniProtKB:P9WKV1}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44726.1; -; Genomic_DNA.
DR   PIR; H70743; H70743.
DR   RefSeq; WP_003402361.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WKV0; -.
DR   SMR; P9WKV0; -.
DR   EnsemblBacteria; AAK44726; AAK44726; MT0503.
DR   KEGG; mtc:MT0503; -.
DR   PATRIC; fig|83331.31.peg.533; -.
DR   HOGENOM; CLU_036604_13_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..438
FT                   /note="Transcriptional regulator MT0503"
FT                   /id="PRO_0000427590"
FT   DNA_BIND        52..73
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250|UniProtKB:P9WKV1"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   438 AA;  46099 MW;  D75B8F6777DE1E6F CRC64;
     MYSTNRTSQS LSRKPGRKHQ LRSHRYVMPP SLHLSDSAAA SVFRAVRLRG PVGRDVIAGS
     TSLSIATVNR QVIALLEAGL LRERADLAVS GAIGRPRVPV EVNHEPFVTL GIHIGARTTS
     IVATDLFGRT LDTVETPTPR NAAGAALTSL ADSADRYLQR WRRRRALWVG VTLGGAVDSA
     TGHVDHPRLG WRQAPVGPVL ADALGLPVSV ASHVDAMAGA ELMLGMRRFA PSSSTSLYVY
     ARETVGYALM IGGRVHCPAS GPGTIAPLPV HSEMLGGTGQ LESTVSDEAV LAAARRLRII
     PGIASRTRTG GSATAITDLL RVARAGNQQA KELLAERARV LGGAVALLRD LLNPDEVVVG
     GQAFTEYPEA MEQVEAAFTA GSVLAPRDIR VTVFGNRVQE AGAGIVSLSG LYADPLGALR
     RSGALDARLQ DTAPEALA
 
 
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