ID   Y4868_NOCFA             Reviewed;         506 AA.
AC   Q5YQ21;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Exopolysaccharide phosphotransferase NFA_48680;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein;
GN   OrderedLocusNames=NFA_48680;
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=247156;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AP006618; BAD59720.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5YQ21; -.
DR   STRING; 247156.NFA_48680; -.
DR   EnsemblBacteria; BAD59720; BAD59720; NFA_48680.
DR   KEGG; nfa:NFA_48680; -.
DR   eggNOG; COG0438; Bacteria.
DR   HOGENOM; CLU_033996_0_0_11; -.
DR   OMA; PTHNSQA; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   InterPro; IPR031356; Stealth_CR4.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
DR   Pfam; PF17103; Stealth_CR4; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Reference proteome; Transferase.
FT   CHAIN           1..506
FT                   /note="Exopolysaccharide phosphotransferase NFA_48680"
FT                   /id="PRO_0000235958"
FT   REGION          484..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  56343 MW;  E2AB06CCC50C8E72 CRC64;
     MRARCGRILS DSERVEADMD TGMGGMDFGT VDAVAGQVAG NLAVSEATIA DLGYLRAQLA
     AAEVPFLLVR DRDHRLVLAA DAAHRAMVRR VTAAAAAAGF VCTQPQPDVV RLGRDRDPAH
     HVELELWEYH GDTVECPRPN ALTRTVFDLA DVEFTEVRLF DRSWPTLAQM FAPQPTDVGF
     DIDIVFSWVD GSDPEFRARR AGMMAQVVVG EGDDADARIR QIDELKYALR SVHKNAPWIR
     RIFIATDSPA PAWLAEHPKV TIVRAIDHFS DTSGLPTFNS HAVESQLQHI EGLSEHFLYS
     NDDMFFARPV RPSMFFTPAG ISRFIEADVR IGPGRNNERR SGYENAARVN RALLAERFGH
     VITRHLEHTP VPLRRSVLRE MEEEFAADFA RTRTSRFRAA TDISVTNSLY HYYALLTGRA
     VPQEAARVAY VDTTSRAGLA VLDDIAAHRD LDFFCLNDGS FPEISESERV REVSRFLAGY
     FPDPAPWERV SAPSRRPLPE STAGAA