ID   Y486_METJA              Reviewed;         322 AA.
AC   Q57910;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Uncharacterized protein MJ0486 {ECO:0000305};
GN   OrderedLocusNames=MJ0486;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250|UniProtKB:Q9X0Z6};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000250|UniProtKB:Q9X0Z6};
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98477.1; -; Genomic_DNA.
DR   PIR; F64360; F64360.
DR   AlphaFoldDB; Q57910; -.
DR   SMR; Q57910; -.
DR   STRING; 243232.MJ_0486; -.
DR   DNASU; 1451348; -.
DR   EnsemblBacteria; AAB98477; AAB98477; MJ_0486.
DR   KEGG; mja:MJ_0486; -.
DR   eggNOG; arCOG01362; Archaea.
DR   HOGENOM; CLU_060920_0_0_2; -.
DR   InParanoid; Q57910; -.
DR   OMA; NAGFTCP; -.
DR   PhylomeDB; Q57910; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.30.20; -; 1.
DR   InterPro; IPR039661; ELP3.
DR   InterPro; IPR006638; Elp3/MiaB/NifB.
DR   InterPro; IPR032432; Radical_SAM_C.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   InterPro; IPR005911; YhcC-like.
DR   PANTHER; PTHR11135; PTHR11135; 1.
DR   PANTHER; PTHR11135:SF1; PTHR11135:SF1; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF16199; Radical_SAM_C; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SFLD; SFLDG01091; uncharacterized_CHP01210-like; 1.
DR   SMART; SM00729; Elp3; 1.
DR   TIGRFAMs; TIGR01212; TIGR01212; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   S-adenosyl-L-methionine.
FT   CHAIN           1..322
FT                   /note="Uncharacterized protein MJ0486"
FT                   /id="PRO_0000106893"
FT   DOMAIN          34..286
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01266"
FT   BINDING         50
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
FT   BINDING         58
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
FT   BINDING         61
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X0Z6"
SQ   SEQUENCE   322 AA;  37390 MW;  F3D074B32180B805 CRC64;
     MVVIMLNYDD IKIIDEIYSE GYLFAQYGIY IKKKFKQKIF KIPVDIGLGC PHKKNGGCIF
     CPEMGRPISV KYCSAKIPLK EQIKKQMENQ KKKGFKKFYI YFYPGTNTYA PAEKLKEIWD
     FSLSYKEVIG LSIGTRPDCL EKEKLDILAE YVENGYDIWI DLGVQSMHQK TLEILNRGHD
     VSDIIKAIKD CHKRGIKVCG HVILGLPGES WKEMMETAKI LSLLEIEAVK IYPLVVVKGT
     KLEEMYWKGE YRTLDENQYI SLVCDFLEHL SPYVLIQRLS KDKVPESIKV SPEWYLGRLK
     IMNKVSEILK KRGTKQGARF FR