ID   Y488_MYCTU              Reviewed;         201 AA.
AC   P9WK33; L0T6U2; P64711; Q11154;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Putative amino-acid transporter Rv0488;
GN   OrderedLocusNames=Rv0488; ORFNames=MTCY20G9.14;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43222.1; -; Genomic_DNA.
DR   PIR; C70744; C70744.
DR   RefSeq; NP_215002.1; NC_000962.3.
DR   RefSeq; WP_003402377.1; NC_000962.3.
DR   AlphaFoldDB; P9WK33; -.
DR   STRING; 83332.Rv0488; -.
DR   PaxDb; P9WK33; -.
DR   GeneID; 887171; -.
DR   KEGG; mtu:Rv0488; -.
DR   TubercuList; Rv0488; -.
DR   eggNOG; COG1279; Bacteria.
DR   OMA; HWWSAGL; -.
DR   PhylomeDB; P9WK33; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IBA:GO_Central.
DR   InterPro; IPR001123; LeuE-type.
DR   InterPro; IPR004777; Lys/arg_exporter.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   TIGRFAMs; TIGR00948; 2a75; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..201
FT                   /note="Putative amino-acid transporter Rv0488"
FT                   /id="PRO_0000103692"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  20951 MW;  E198975DF088E6E4 CRC64;
     MMTLKVAIGP QNAFVLRQGI RREYVLVIVA LCGIADGALI AAGVGGFAAL IHAHPNMTLV
     ARFGGAAFLI GYALLAARNA WRPSGLVPSE SGPAALIGVV QMCLVVTFLN PHVYLDTVVL
     IGALANEESD LRWFFGAGAW AASVVWFAVL GFSAGRLQPF FATPAAWRIL DALVAVTMIG
     VAVVVLVTSP SVPTANVALI I