ID   Y489_MYCLE              Reviewed;         555 AA.
AC   Q49646; O69487;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized lipoprotein ML0489;
DE   Flags: Precursor;
GN   OrderedLocusNames=ML0489; ORFNames=B1177_C2_197, MLCB1259.07;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: To M.tuberculosis Rv2585c and M.bovis Mb2616c.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA17096.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U00011; AAA17096.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AL023591; CAA19082.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29997.1; -; Genomic_DNA.
DR   PIR; A86970; A86970.
DR   PIR; S72732; S72732.
DR   RefSeq; NP_301429.1; NC_002677.1.
DR   RefSeq; WP_010907753.1; NC_002677.1.
DR   AlphaFoldDB; Q49646; -.
DR   SMR; Q49646; -.
DR   STRING; 272631.ML0489; -.
DR   PRIDE; Q49646; -.
DR   EnsemblBacteria; CAC29997; CAC29997; CAC29997.
DR   KEGG; mle:ML0489; -.
DR   PATRIC; fig|272631.5.peg.853; -.
DR   Leproma; ML0489; -.
DR   eggNOG; COG0747; Bacteria.
DR   HOGENOM; CLU_017028_11_2_11; -.
DR   OMA; WNMDRWV; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039424; SBP_5.
DR   InterPro; IPR000914; SBP_5_dom.
DR   PANTHER; PTHR30290; PTHR30290; 1.
DR   Pfam; PF00496; SBP_bac_5; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           29..555
FT                   /note="Uncharacterized lipoprotein ML0489"
FT                   /id="PRO_0000014138"
FT   LIPID           29
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           29
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   555 AA;  58108 MW;  91CF880D41D55E2F CRC64;
     MRSGLFGVLR WTAVGLVATL VASLALTACS GSAAGEIVYV VDGALGTYNT NTIVGAASAG
     AQAFARTLIG FGYHGPDGQI VADHDFGTIT VVGGVPLVLD YQIADNAVYS DGKQVTCDDL
     VLTWAAQSGR FPGFDAATQA GYRDIANIEC LAGQKKSRVF FVPDRSVVDY EQLFAATSMM
     PSHVIADQLN IDVTEALLTH NATLVEQIAR LWNTTWDLKP AVDLRRFPSS GPYKIESVLN
     GGAVVLVAND RWWGLKATTK RITVRPQEAD IQDRVNNRSV DVVDVAVGSS GSLATPDNYA
     RIDSPSAGIE QLIFAPQGLL AAAAARRALA LCTPRDVVAR DAGLSIANSR LSPATEDAIA
     AADGAREAGQ FSKADPAAAH DALSGETLPV RIGYQGPNAR LAATVGTIAK ACAVAGISVS
     SVTLDSSTDP SGPQALRDGK IDVLLASTGG ATGSGSSGSS SMDAYDLHTG NGNNLSGYAN
     AQVDNNIGAL AVSADPAERV RLLADSAPVL WADMPTLPLY RQQRMLLMSK TMYAVTRNPT
     RWGAGWNMDR WALVR