ID   Y492_MYCTU              Reviewed;         629 AA.
AC   P9WMV7; L0T3X0; Q11157;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Uncharacterized GMC-type oxidoreductase Rv0492c;
DE            EC=1.1.-.-;
GN   OrderedLocusNames=Rv0492c; ORFNames=MTCY20G9.18c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43226.1; -; Genomic_DNA.
DR   PIR; G70744; G70744.
DR   RefSeq; NP_215006.2; NC_000962.3.
DR   RefSeq; WP_003908534.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WMV7; -.
DR   SMR; P9WMV7; -.
DR   STRING; 83332.Rv0492c; -.
DR   PaxDb; P9WMV7; -.
DR   GeneID; 887199; -.
DR   KEGG; mtu:Rv0492c; -.
DR   TubercuList; Rv0492c; -.
DR   eggNOG; COG2303; Bacteria.
DR   OMA; QTQGYVR; -.
DR   PhylomeDB; P9WMV7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   1: Evidence at protein level;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..629
FT                   /note="Uncharacterized GMC-type oxidoreductase Rv0492c"
FT                   /id="PRO_0000205615"
FT   ACT_SITE        562
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:E4QP00"
SQ   SEQUENCE   629 AA;  66154 MW;  A3F62AFCDA03D23C CRC64;
     MSRLADRAKS YPLASFGAAL LPPELGGPLP AQFVQRVDRY VTRLPATSRF AVRAGLASLA
     AASYLTTGRS LPRLHPDERA RVLHRIAALS PEVAAAVEGL KAIVLLANGA DTYAHELLAR
     AQEHDAARPD AELTVILSAD SPSVTRADAV VVGSGAGGAM VARTLARAGL DVVVLEEGRR
     WTVEEFRSTH PVDRYAGLYR GAGATVALGR PAVVLPMGRA VGGTTVVNSG TCFRPSLAVQ
     RRWRDEFGLG LADPDQLGRR LDDAEQTLRV APVPLEIMGR NGRLLLQAAK SLGWRAAPIP
     RNAPGCRGCC QCAIGCPSNA KFGVHLNALP QACAAGARII SWARVERILH RAGRAYGVRA
     RRPDGTTLDV LADAVVVAAG ATETPGLLRR SGLGGHPRLG HNLALHPATM LAGLFDDDVF
     AWRGVLQSAA VHEFHESDGV LIEATSTPPG MGSMVFPGYG AELLRWLDRA PQIATFGAMV
     ADRGVGTVRS VRGETVVRYD IAPGEIAKLR VALQAIGRLL FAAGAVEVLT GIPGAPPMRS
     LPELQDVLRR ANPRSLHLAA FHPTGTAAAG ADEQLCPVDA TGRLRGVEGV WVADASILPS
     CPEVNPQLSI MAMALAVADQ TVAKVVGVR