ID   Y494_MYCTU              Reviewed;         242 AA.
AC   P9WMG7; L0T5J2; P67739; Q11159;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv0494;
GN   OrderedLocusNames=Rv0494; ORFNames=MTCY20G9.20;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP43229.1; -; Genomic_DNA.
DR   PIR; A70745; A70745.
DR   RefSeq; NP_215008.2; NC_000962.3.
DR   RefSeq; WP_003402414.1; NC_000962.3.
DR   AlphaFoldDB; P9WMG7; -.
DR   SMR; P9WMG7; -.
DR   STRING; 83332.Rv0494; -.
DR   PaxDb; P9WMG7; -.
DR   DNASU; 887166; -.
DR   GeneID; 887166; -.
DR   KEGG; mtu:Rv0494; -.
DR   PATRIC; fig|83332.111.peg.543; -.
DR   TubercuList; Rv0494; -.
DR   eggNOG; COG2186; Bacteria.
DR   OMA; EDFHRTI; -.
DR   PhylomeDB; P9WMG7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..242
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv0494"
FT                   /id="PRO_0000050697"
FT   DOMAIN          17..85
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        45..64
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   242 AA;  26015 MW;  3E927CFC4A6FC1C5 CRC64;
     MVEPMNQSSV FQPPDRQRVD ERIATTIADA ILDGVFPPGS TLPPERDLAE RLGVNRTSLR
     QGLARLQQMG LIEVRHGSGS VVRDPEGLTH PAVVEALVRK LGPDFLVELL EIRAALGPLI
     GRLAAARSTP EDAEALCAAL EVVQQADTAA ARQAADLAYF RVLIHSTRNR ALGLLYRWVE
     HAFGGREHAL TGAYDDADPV LTDLRAINGA VLAGDPAAAA ATVEAYLNAS ALRMVKSYRD
     RA