Y4951_DROME
ID Y4951_DROME Reviewed; 446 AA.
AC A1A708; A1A6Y7; A1A731; A2RVH9; Q7K2Q3; Q95SK4; Q9VAY1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Uncharacterized protein CG4951;
GN ORFNames=CG4951;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-307, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-202; SER-212;
RP SER-214 AND SER-251, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=A1A708-1; Sequence=Displayed;
CC Name=A;
CC IsoId=A1A708-2; Sequence=VSP_037163;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28287.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=ABL75717.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF56766.2; -; Genomic_DNA.
DR EMBL; AE014297; ABW08788.1; -; Genomic_DNA.
DR EMBL; AY060739; AAL28287.2; ALT_INIT; mRNA.
DR EMBL; BT029659; ABL75717.1; ALT_FRAME; mRNA.
DR EMBL; BT029681; ABL75738.1; -; mRNA.
DR EMBL; BT029704; ABL75761.1; -; mRNA.
DR EMBL; BT029719; ABL75776.1; -; mRNA.
DR EMBL; BT029970; ABM92844.1; -; mRNA.
DR EMBL; BT030265; ABN49404.1; -; mRNA.
DR RefSeq; NP_001097950.1; NM_001104480.2. [A1A708-1]
DR RefSeq; NP_651602.1; NM_143345.2. [A1A708-2]
DR AlphaFoldDB; A1A708; -.
DR IntAct; A1A708; 6.
DR iPTMnet; A1A708; -.
DR PaxDb; A1A708; -.
DR PRIDE; A1A708; -.
DR DNASU; 43355; -.
DR EnsemblMetazoa; FBtr0085265; FBpp0084634; FBgn0039563. [A1A708-2]
DR EnsemblMetazoa; FBtr0113298; FBpp0112210; FBgn0039563. [A1A708-1]
DR GeneID; 43355; -.
DR KEGG; dme:Dmel_CG4951; -.
DR UCSC; CG4951-RA; d. melanogaster.
DR UCSC; CG4951-RB; d. melanogaster. [A1A708-1]
DR FlyBase; FBgn0039563; CG4951.
DR VEuPathDB; VectorBase:FBgn0039563; -.
DR eggNOG; ENOG502TBUA; Eukaryota.
DR HOGENOM; CLU_047757_0_0_1; -.
DR InParanoid; A1A708; -.
DR OMA; NYMSIDH; -.
DR PhylomeDB; A1A708; -.
DR BioGRID-ORCS; 43355; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG4951; fly.
DR GenomeRNAi; 43355; -.
DR PRO; PR:A1A708; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039563; Expressed in ovary and 51 other tissues.
DR Genevisible; A1A708; DM.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..446
FT /note="Uncharacterized protein CG4951"
FT /id="PRO_0000372642"
FT REGION 141..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 200
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 202
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 214
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 251
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 282
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT VAR_SEQ 321..446
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_037163"
FT CONFLICT 242
FT /note="A -> P (in Ref. 3; ABM92844)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="E -> D (in Ref. 3; ABM92844)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 50753 MW; CD15D5C384C65F3E CRC64;
MSFSAIGDCQ LISQLYQYKK HRVICSVKVL PTPVTHFERE SKNDFHWMTA DRWSRIECGL
WRLFENLKQW QDAYQLDTEL IIDHIIVRVQ ATNKSHPATV ALLAGTESSS KDLCLDLQLQ
YITQEDTTIV DVIPAKRELA TEAETNGTRP TSRKIRVANS GSKPKAGTQS KPKHIDADNE
DDKSSTTASQ PTKIKSERRS ISQGGEKDKA SSSSPSSSQQ SNRIKRSHSP SQQNSRSSSV
EAKPARRSGR SPIRPSRFKN FVVGETRSGK SRGPKPKVKR VSPVPAKDFK VEHMDGGRFN
ALQRLDSMLD TPKPREVKIL LLEKMGEDEV LNTFENYRSD FDKLFKEREF KPRTSHYMNI
AHMDVIDILS KSIHQQMLKK LGEVYSSRSN HTSLLVNGLL PLWIVRLFMD TYTLSQSEAV
QQIRDQMKYN TYLRALNDEP LSSDLD
