ID   CAS2_STRMN              Reviewed;         107 AA.
AC   C6SPT0;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=CRISPR-associated endoribonuclease Cas2 {ECO:0000255|HAMAP-Rule:MF_01471};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01471};
GN   Name=cas2 {ECO:0000255|HAMAP-Rule:MF_01471};
GN   OrderedLocusNames=SmuNN2025_0696;
OS   Streptococcus mutans serotype c (strain NN2025).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=511691;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NN2025;
RX   PubMed=19656368; DOI=10.1186/1471-2164-10-358;
RA   Maruyama F., Kobata M., Kurokawa K., Nishida K., Sakurai A., Nakano K.,
RA   Nomura R., Kawabata S., Ooshima T., Nakai K., Hattori M., Hamada S.,
RA   Nakagawa I.;
RT   "Comparative genomic analyses of Streptococcus mutans provide insights into
RT   chromosomal shuffling and species-specific content.";
RL   BMC Genomics 10:358-358(2009).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat), is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain sequences complementary to
CC       antecedent mobile elements and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA).
CC       Functions as a ssRNA-specific endoribonuclease. Involved in the
CC       integration of spacer DNA into the CRISPR cassette. {ECO:0000255|HAMAP-
CC       Rule:MF_01471}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01471};
CC   -!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas1 homodimer.
CC       {ECO:0000255|HAMAP-Rule:MF_01471}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated endoribonuclease Cas2
CC       protein family. {ECO:0000255|HAMAP-Rule:MF_01471}.
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DR   EMBL; AP010655; BAH87722.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6SPT0; -.
DR   SMR; C6SPT0; -.
DR   KEGG; smc:SmuNN2025_0696; -.
DR   HOGENOM; CLU_150500_1_1_9; -.
DR   OMA; TDKQFGM; -.
DR   GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR   GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01471; Cas2; 1.
DR   InterPro; IPR021127; CRISPR_associated_Cas2.
DR   InterPro; IPR019199; Virulence_VapD/CRISPR_Cas2.
DR   Pfam; PF09827; CRISPR_Cas2; 1.
DR   TIGRFAMs; TIGR01573; cas2; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Endonuclease; Hydrolase; Magnesium; Metal-binding;
KW   Nuclease.
FT   CHAIN           1..107
FT                   /note="CRISPR-associated endoribonuclease Cas2"
FT                   /id="PRO_0000417730"
FT   BINDING         6
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01471"
SQ   SEQUENCE   107 AA;  12346 MW;  11E61985CE45B131 CRC64;
     MILMFDMPTD TAEERKAYRK FRKFLLSEGF IMHQFSVYSK LLLNNSANTA MIARLKENNP
     KKGNITLLTV TEKQFARMIY LNGERDTSIA NSDSRLVFLG EAFPDET