ID   Y4UC_SINFN              Reviewed;         512 AA.
AC   Q53197;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative aldehyde-dehydrogenase-like protein y4uC;
DE            EC=1.2.1.-;
GN   OrderedLocusNames=NGR_a01370; ORFNames=y4uC;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8796346; DOI=10.1101/gr.6.7.590;
RA   Freiberg C., Perret X., Broughton W.J., Rosenthal A.;
RT   "Sequencing the 500-kb GC-rich symbiotic replicon of Rhizobium sp. NGR234
RT   using dye terminators and a thermostable 'sequenase': a beginning.";
RL   Genome Res. 6:590-600(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Could be a succinate-semialdehyde dehydrogenase (NADP(+)).
CC   -!- PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; Z68203; CAA92404.1; -; Genomic_DNA.
DR   EMBL; U00090; AAB91875.1; -; Genomic_DNA.
DR   RefSeq; NP_444088.1; NC_000914.2.
DR   AlphaFoldDB; Q53197; -.
DR   SMR; Q53197; -.
DR   STRING; 394.NGR_a01370; -.
DR   EnsemblBacteria; AAB91875; AAB91875; NGR_a01370.
DR   KEGG; rhi:NGR_a01370; -.
DR   PATRIC; fig|394.7.peg.122; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_5; -.
DR   OMA; FAMTEMT; -.
DR   OrthoDB; 384611at2; -.
DR   UniPathway; UPA00733; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Plasmid; Reference proteome.
FT   CHAIN           1..512
FT                   /note="Putative aldehyde-dehydrogenase-like protein y4uC"
FT                   /id="PRO_0000056599"
FT   REGION          14..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        286
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        320
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   BINDING         266..271
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   512 AA;  55360 MW;  BEB862162FD251E9 CRC64;
     MDAGRRRLVI NDCMKPERGR RSPLPRRPTR PPDERSSGIG NLAMTPAKLH MTTSLAPIAV
     HSPYDGSLLG SVEATDPADI DRLLATARRG AEISRNLPRH KRASILEGAA QMVESRHDAF
     AEIIVREAGK TIVQARKEVL RCVNTLKLSA EEAKRNAGEI VPFDAYTGSE QRQGWFTRDP
     LGIITAITPY NDPLNLVAHK LGPAIAGGNA VMLKPSNLTP FSAIKLVGAL REAGLPEEVI
     TISHGDRELV TAMIAAREVR MVSFTGGFAT GEAISRAAGL KKLAMELGGN APVIVMNDCD
     FDKAVEGCVS GAFWAAGQNC IGAQRILIQS ELYGRFRDAF VAATKKLKAG DPLQEDTDVG
     PMISKQVAER TEAAVNEAIK AGATLLCGNY REGSLYHPTV LEGTPLTCRL WHEEVFAPVV
     MLAPFDTLDK GIEMANDPDY SLHAGIFTND LNVALEAANR IEVGGVMIND SSDYRFDAMP
     FGGFKYGSMG REGVRFAYED MTQPKVVCIN RG