ID   Y4VG_SINFN              Reviewed;         414 AA.
AC   Q53215;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Probable cytochrome P450 127A1;
DE            EC=1.14.14.-;
GN   Name=cyp127A1; OrderedLocusNames=NGR_a01170; ORFNames=y4vG;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8796346; DOI=10.1101/gr.6.7.590;
RA   Freiberg C., Perret X., Broughton W.J., Rosenthal A.;
RT   "Sequencing the 500-kb GC-rich symbiotic replicon of Rhizobium sp. NGR234
RT   using dye terminators and a thermostable 'sequenase': a beginning.";
RL   Genome Res. 6:590-600(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       They oxidize a variety of structurally unrelated compounds, including
CC       steroids, fatty acids, and xenobiotics.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; Z68203; CAA92422.1; -; Genomic_DNA.
DR   EMBL; U00090; AAB91895.1; -; Genomic_DNA.
DR   RefSeq; NP_444108.1; NC_000914.2.
DR   AlphaFoldDB; Q53215; -.
DR   SMR; Q53215; -.
DR   STRING; 394.NGR_a01170; -.
DR   EnsemblBacteria; AAB91895; AAB91895; NGR_a01170.
DR   KEGG; rhi:NGR_a01170; -.
DR   PATRIC; fig|394.7.peg.101; -.
DR   eggNOG; COG2124; Bacteria.
DR   HOGENOM; CLU_033716_0_1_5; -.
DR   OMA; QEMISTC; -.
DR   OrthoDB; 816674at2; -.
DR   Proteomes; UP000001054; Plasmid sym pNGR234a.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR002397; Cyt_P450_B.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00359; BP450.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   3: Inferred from homology;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Plasmid;
KW   Reference proteome.
FT   CHAIN           1..414
FT                   /note="Probable cytochrome P450 127A1"
FT                   /id="PRO_0000052311"
FT   BINDING         364
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   414 AA;  45811 MW;  888598E99315BBB4 CRC64;
     MSDLRRKRVK TNPIPDHVPP ALVRHFSLFT SPGMAPTPNG DPHAAVACVH DDGPPIFYSP
     SNTRDGRGTW VITRARDQRR VLEDTETFSS HRSIFASALG EHWPVIPLEL DPPAHGVFRA
     LLNPLFSSRR VLALEPTIHA RAGALIDCIA KEKTSCDVMK DFALPFTFSV FLSFLGLSQR
     RSEVLVGWVS DLLHGNAEKR RAAARSVVAF IDEMAAMRRK SPAVDFMTFV VQAKIEGRSL
     TEEEVRGIGV LFLVAGLDTV AAAIGFDMAY LARNPKHQEL LRNEPARLGL AAEELLRAYS
     TVQIIRVATK DIEFEGVPIR EGDYVSCPAM IANRDPSEFK CPNTIDLARQ DNQHTAFGYG
     PHLCHGAHLA RREIVIGLRE WLARIPAFRI KEGTAPITHG GHVFGISNII LTWA