Y5053_ARATH
ID Y5053_ARATH Reviewed; 548 AA.
AC Q0WLC7; Q8GY40; Q9LUF7;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=CBS domain-containing protein CBSCBSPB4;
GN Name=CBSCBSPB4; OrderedLocusNames=At5g50530; ORFNames=MBA10.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19400948; DOI=10.1186/1471-2164-10-200;
RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.;
RT "Genome wide expression analysis of CBS domain containing proteins in
RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their
RT developmental and stress regulation.";
RL BMC Genomics 10:200-200(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0WLC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0WLC7-2; Sequence=VSP_041669;
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DR EMBL; AB025619; BAB09138.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95955.1; -; Genomic_DNA.
DR EMBL; AK117882; BAC42522.1; -; mRNA.
DR EMBL; AK230278; BAF02080.1; -; mRNA.
DR RefSeq; NP_568736.1; NM_124440.3. [Q0WLC7-1]
DR RefSeq; NP_680412.1; NM_148107.2. [Q0WLC7-1]
DR AlphaFoldDB; Q0WLC7; -.
DR SMR; Q0WLC7; -.
DR STRING; 3702.AT5G50530.1; -.
DR iPTMnet; Q0WLC7; -.
DR PaxDb; Q0WLC7; -.
DR PRIDE; Q0WLC7; -.
DR EnsemblPlants; AT5G50530.1; AT5G50530.1; AT5G50530. [Q0WLC7-1]
DR EnsemblPlants; AT5G50640.1; AT5G50640.1; AT5G50640. [Q0WLC7-1]
DR GeneID; 835121; -.
DR GeneID; 835133; -.
DR Gramene; AT5G50530.1; AT5G50530.1; AT5G50530. [Q0WLC7-1]
DR Gramene; AT5G50640.1; AT5G50640.1; AT5G50640. [Q0WLC7-1]
DR KEGG; ath:AT5G50530; -.
DR KEGG; ath:AT5G50640; -.
DR Araport; AT5G50530; -.
DR TAIR; locus:2159762; AT5G50530.
DR eggNOG; ENOG502QVK2; Eukaryota.
DR HOGENOM; CLU_009026_3_0_1; -.
DR InParanoid; Q0WLC7; -.
DR OMA; KNWGASI; -.
DR PhylomeDB; Q0WLC7; -.
DR PRO; PR:Q0WLC7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WLC7; baseline and differential.
DR Genevisible; Q0WLC7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR Gene3D; 3.10.580.10; -; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR034896; CBSCBSPB.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR13780:SF48; PTHR13780:SF48; 1.
DR Pfam; PF00571; CBS; 4.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00116; CBS; 4.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54631; SSF54631; 2.
DR PROSITE; PS51371; CBS; 4.
DR PROSITE; PS51745; PB1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; CBS domain; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..548
FT /note="CBS domain-containing protein CBSCBSPB4"
FT /id="PRO_0000412230"
FT TRANSMEM 521..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 63..126
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 133..190
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 233..293
FT /note="CBS 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 301..358
FT /note="CBS 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 411..498
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT VAR_SEQ 1..253
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074, ECO:0000303|Ref.4"
FT /id="VSP_041669"
FT CONFLICT 262
FT /note="S -> G (in Ref. 3; BAC42522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 548 AA; 59812 MW; BD5533B551ADC870 CRC64;
MANQGGPSRK SLSFSGHSFQ GRKKASENEG GGGGGSDLLP RRSLTSSRSS ISLSGERSGE
RTVKRLRLCK ALTVPDSTTL FEACRRMAAR RVDALLLTDS NALLCGILTD RDIATKVIAK
QLNLEETPVS KVMTKNPVFV LSDTIAVEAL QKMVQGKFRH LPVVENGEVI ALLDIAKCLY
DAIARMERSV EKGKAIAAAV EGVEKNWGTS IAGPNTFMET LRERIFKPSL STIIPENTKV
LKVGLDETVL GVTMKMVEYQ SSAAMVMVEN KLVGILTSKD ILMRVISQNL PQETTTVEKV
MTPNPESATV DMAIVEALHI MHNGKFLHLP VLDKDGDVVA VIDVIHITHA AVTTAGSTAG
INNETANSMM QKFWDSAMAL SPNEDGDETR SEEESMKLSS EIEVTKSFSY PNTFAFKLQD
KKGRMHRFMC ETQSLTTLIT AILQRMGDDI EPDNLPQIMY EDEDNDKVVL ASDNDLGAAV
EHAKSIGWKG LKLHLDYTEE RGHRRGLSSE DMDYDQSNSW AAAYKTVAAG AALAAGLGVL
VYLKRNSN
