Y505_ZYMMO
ID Y505_ZYMMO Reviewed; 219 AA.
AC O66114; Q5NQ76;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase ZMO0505;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=ZMO0505;
OS Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Zymomonadaceae; Zymomonas.
OX NCBI_TaxID=264203;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 29191 / DSM 3580 / JCM 10190 / CECT 560 / NBRC 13756 / NCIMB
RC 11199 / NRRL B-4490 / ZM6;
RX PubMed=9515924; DOI=10.1128/jb.180.6.1540-1548.1998;
RA Neveling U., Klasen R., Bringer-Meyer S., Sahm H.;
RT "Purification of the pyruvate dehydrogenase multienzyme complex of
RT Zymomonas mobilis and identification and sequence analysis of the
RT corresponding genes.";
RL J. Bacteriol. 180:1540-1548(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RX PubMed=15592456; DOI=10.1038/nbt1045;
RA Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA Kang H.S.;
RT "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT ZM4.";
RL Nat. Biotechnol. 23:63-68(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; X93605; CAA63803.1; -; Genomic_DNA.
DR EMBL; AE008692; AAV89129.1; -; Genomic_DNA.
DR RefSeq; WP_011240409.1; NZ_CP035711.1.
DR AlphaFoldDB; O66114; -.
DR SMR; O66114; -.
DR STRING; 264203.ZMO0505; -.
DR EnsemblBacteria; AAV89129; AAV89129; ZMO0505.
DR GeneID; 58026340; -.
DR KEGG; zmo:ZMO0505; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_11_1_5; -.
DR OMA; SICLHAW; -.
DR OrthoDB; 1714699at2; -.
DR Proteomes; UP000001173; Chromosome.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome.
FT CHAIN 1..219
FT /note="Uncharacterized RNA pseudouridine synthase ZMO0505"
FT /id="PRO_0000162748"
FT ACT_SITE 58
FT /evidence="ECO:0000250"
FT CONFLICT 6
FT /note="K -> E (in Ref. 1; CAA63803)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="I -> T (in Ref. 1; CAA63803)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="G -> S (in Ref. 1; CAA63803)"
FT /evidence="ECO:0000305"
FT CONFLICT 205
FT /note="T -> A (in Ref. 1; CAA63803)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 24409 MW; 76B007DF068427C3 CRC64;
MPILAKRVLF IDAEAMIIDK PAGLPVTSVR DGSLSLENYL ASLCFGFKRW PSIVHRLDRD
TSGCLLLARN PKMHRRLSEA FSQGQVKKCY WAILEGVPEK NEGIIDLPLL KISSPKSGWR
IVADDKGKRA VTHWEILAKN KGRSLVAFRP ETGRTHQLRV HAATGLGLPI VGDPFYGSHK
DENISRMMLH AHSLEIARLE KKPITAEAPL PKAFTDLGF
