Y5076_DROME
ID Y5076_DROME Reviewed; 619 AA.
AC C0HK92; B9EQU5; Q95S18; Q9VGX1; Q9VGX2; Q9VGX3; Q9Y0F9;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2016, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Uncharacterized protein CG45076 {ECO:0000305};
GN ORFNames=CG45076 {ECO:0000312|FlyBase:FBgn0266446};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL28545.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000312|EMBL:ACM16737.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E).
RA Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.;
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79 AND SER-81, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A {ECO:0000312|FlyBase:FBgn0266446}; Synonyms=H
CC {ECO:0000312|FlyBase:FBgn0266446};
CC IsoId=C0HK92-1; Sequence=Displayed;
CC Name=E {ECO:0000312|FlyBase:FBgn0266446}; Synonyms=I
CC {ECO:0000312|FlyBase:FBgn0266446};
CC IsoId=C0HK92-2; Sequence=VSP_058686, VSP_058687;
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DR EMBL; AE014297; AAF54549.3; -; Genomic_DNA.
DR EMBL; AE014297; AHN57273.1; -; Genomic_DNA.
DR EMBL; AE014297; AHN57275.1; -; Genomic_DNA.
DR EMBL; AY060997; AAL28545.1; -; mRNA.
DR EMBL; BT058020; ACM16737.1; -; mRNA.
DR RefSeq; NP_001287274.1; NM_001300345.1. [C0HK92-2]
DR RefSeq; NP_001287275.1; NM_001300346.1. [C0HK92-1]
DR RefSeq; NP_001287276.1; NM_001300347.1. [C0HK92-2]
DR RefSeq; NP_650015.3; NM_141758.5. [C0HK92-1]
DR AlphaFoldDB; C0HK92; -.
DR IntAct; C0HK92; 3.
DR STRING; 7227.FBpp0081783; -.
DR iPTMnet; C0HK92; -.
DR PRIDE; C0HK92; -.
DR DNASU; 19834760; -.
DR EnsemblMetazoa; FBtr0344440; FBpp0310812; FBgn0266446. [C0HK92-1]
DR EnsemblMetazoa; FBtr0344441; FBpp0310813; FBgn0266446. [C0HK92-2]
DR EnsemblMetazoa; FBtr0344442; FBpp0310814; FBgn0266446. [C0HK92-1]
DR EnsemblMetazoa; FBtr0344443; FBpp0310815; FBgn0266446. [C0HK92-2]
DR GeneID; 19834760; -.
DR KEGG; dme:Dmel_CG45076; -.
DR FlyBase; FBgn0266446; CG45076.
DR VEuPathDB; VectorBase:FBgn0266446; -.
DR eggNOG; ENOG502S3AX; Eukaryota.
DR OMA; HFSYHYP; -.
DR BioGRID-ORCS; 19834760; 0 hits in 1 CRISPR screen.
DR ChiTaRS; CG45076; fly.
DR GenomeRNAi; 19834760; -.
DR PRO; PR:C0HK92; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0266446; Expressed in thoracico-abdominal ganglion (Drosophila) and 21 other tissues.
DR ExpressionAtlas; C0HK92; baseline and differential.
DR Genevisible; Q9VGX3; DM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..619
FT /note="Uncharacterized protein CG45076"
FT /id="PRO_0000438590"
FT REGION 285..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..504
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..619
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 280..343
FT /note="DAELDPNRPSRKFSAPRPLEDPLDVEAKEKQRLRQERLLTVNEEALDEVDLE
FT KKRAQKADEAKR -> GKSHLASVRICGDKAYNVRSPLYDTDKVRTDINLLSWYLRHPT
FT WKNDKKSQDPVKEVEAVEVEA (in isoform E)"
FT /id="VSP_058686"
FT VAR_SEQ 344..619
FT /note="Missing (in isoform E)"
FT /id="VSP_058687"
SQ SEQUENCE 619 AA; 68642 MW; 7DDCB26AD1AB9CEE CRC64;
MVYESGFTTR RTYSSRPVTT SYAVTYPSVE KVTRVYKSSY PIYSSYSVPR RVYGATRVVT
SPIRVVTSPA RVVSRVIHSP SPVRVVRTTT RVISSPERTT YSYTTPSTYY SPSYLPSTYT
STYIPTSYTT YTPSYAYSPT TVTRVYAPRS SLSPLRITPS PVRVITSPVR SVPSYLKRLP
PGYGARALTN YLNTEPFTTF SEETSRIRNR AQSLIRDLHT PVVRRARSCT PFPVTGYTYE
PASQLALDAY VARVTNPVRH IAKEVHNISH YPRPAVKYVD AELDPNRPSR KFSAPRPLED
PLDVEAKEKQ RLRQERLLTV NEEALDEVDL EKKRAQKADE AKRREERALK EERDRLTAEA
EKQAAAKAKK AAEEAAKIAA EEALLAEAAA QKAAEEAKAL KAAEDAAQKA AEEARLAEEA
AAQKVAEEAA QKAAEEARLA EEAAAQKAAE EAAQKAAEEA ALKAAEEARL AEEAAQKAAE
EAALKAVEEA RAAEEAAQKA AEEARVAEEA RLEEEQRVRE QELERLAEIE KESEGELARQ
AAELAEIARQ ESELAAQELQ AIQKNENETS EPVVEEPVTP VEEQEPIIEL GSNVTPTGGN
SYEEDLDAEE EEDEEEEEE
