ID   CAS5C_SACS2             Reviewed;         240 AA.
AC   Q97WW2;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=CRISPR-associated protein Cas5 3;
GN   Name=cas5c; OrderedLocusNames=SSO1998;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the aCascade ribonucleoprotein complex. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC       Subtype I-A/Apern subfamily. {ECO:0000305}.
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DR   EMBL; AE006641; AAK42188.1; -; Genomic_DNA.
DR   PIR; E90366; E90366.
DR   RefSeq; WP_009991627.1; NC_002754.1.
DR   AlphaFoldDB; Q97WW2; -.
DR   SMR; Q97WW2; -.
DR   STRING; 273057.SSO1998; -.
DR   EnsemblBacteria; AAK42188; AAK42188; SSO1998.
DR   GeneID; 7806460; -.
DR   GeneID; 8760766; -.
DR   KEGG; sso:SSO1998; -.
DR   PATRIC; fig|273057.12.peg.2075; -.
DR   eggNOG; arCOG02670; Archaea.
DR   HOGENOM; CLU_1154391_0_0_2; -.
DR   InParanoid; Q97WW2; -.
DR   OMA; CKECLVS; -.
DR   PhylomeDB; Q97WW2; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR   InterPro; IPR010153; CRISPR-assoc_prot_Cas5a-typ.
DR   TIGRFAMs; TIGR01874; cas_cas5a; 1.
DR   TIGRFAMs; TIGR02593; CRISPR_cas5; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..240
FT                   /note="CRISPR-associated protein Cas5 3"
FT                   /id="PRO_0000417894"
SQ   SEQUENCE   240 AA;  27211 MW;  30B5FA2A8A3A9A58 CRC64;
     MIYSKVFLKL HWGFSVVKPS AAKAKSGFYL PPPTTLIGAL SYGKFRGIDN TNLGKIYGSP
     AYNFRNVMAT ARLESEGAYT EDIVRNVISY FQRKDRRDNP RYIYGVIPTG KVYMPNGTLV
     VVYVTDSMSK EELEKLSWSI TRIGGKECLV SVENVEIGEA KKVSGRMKTR YYFRDTVKVV
     GKKEFLEYVT FWEENGYIWG KEGGPIRYIL PVATYPLASK EVEVEAKEAY EVGGEYVVFS