Y5098_DROME
ID Y5098_DROME Reviewed; 1238 AA.
AC Q6AWG9; A8DYH9;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Uncharacterized protein CG5098;
GN ORFNames=CG5098;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453; THR-642; SER-682;
RP SER-749; SER-753; SER-793; SER-799 AND SER-1099, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=Q6AWG9-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q6AWG9-2; Sequence=VSP_035949, VSP_035950;
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DR EMBL; AE013599; AAF57755.1; -; Genomic_DNA.
DR EMBL; AE013599; ABV53840.1; -; Genomic_DNA.
DR EMBL; BT015279; AAT94508.1; -; mRNA.
DR RefSeq; NP_001097363.1; NM_001103893.2. [Q6AWG9-2]
DR RefSeq; NP_611291.1; NM_137447.4. [Q6AWG9-1]
DR AlphaFoldDB; Q6AWG9; -.
DR BioGRID; 62747; 3.
DR IntAct; Q6AWG9; 2.
DR STRING; 7227.FBpp0112005; -.
DR iPTMnet; Q6AWG9; -.
DR PaxDb; Q6AWG9; -.
DR EnsemblMetazoa; FBtr0086732; FBpp0085911; FBgn0034300. [Q6AWG9-1]
DR EnsemblMetazoa; FBtr0113092; FBpp0112005; FBgn0034300. [Q6AWG9-2]
DR GeneID; 37063; -.
DR KEGG; dme:Dmel_CG5098; -.
DR UCSC; CG5098-RA; d. melanogaster. [Q6AWG9-1]
DR UCSC; CG5098-RB; d. melanogaster.
DR FlyBase; FBgn0034300; CG5098.
DR VEuPathDB; VectorBase:FBgn0034300; -.
DR eggNOG; KOG1084; Eukaryota.
DR GeneTree; ENSGT00940000172444; -.
DR HOGENOM; CLU_259871_0_0_1; -.
DR InParanoid; Q6AWG9; -.
DR OMA; DRKVYCQ; -.
DR BioGRID-ORCS; 37063; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37063; -.
DR PRO; PR:Q6AWG9; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034300; Expressed in egg cell and 25 other tissues.
DR ExpressionAtlas; Q6AWG9; baseline and differential.
DR Genevisible; Q6AWG9; DM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PROSITE; PS51805; EPHD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; Phosphoprotein; Reference proteome;
KW Zinc; Zinc-finger.
FT CHAIN 1..1238
FT /note="Uncharacterized protein CG5098"
FT /id="PRO_0000355631"
FT ZN_FING 1089..1131
FT /note="C2HC pre-PHD-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 1151..1199
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT REGION 22..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 642
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 682
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 749
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 753
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 793
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 799
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1099
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1
FT /note="M -> MANNNHPHPGHLSQAAQNASWNPLQIPSYIPRQPQLAHMSNERPGMV
FT RSPLAWHVSGTVSAQPPPPPDAIYNFMSANHKNLDHHHQM (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_035949"
FT VAR_SEQ 208..209
FT /note="KP -> KRKTHA (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_035950"
SQ SEQUENCE 1238 AA; 133869 MW; 1FE800C3635F0257 CRC64;
MNPLLAPPYS GTLPFNSMDL SLQSARSAAQ PLAKQPPNQQ PHQTQQQQQS LIHAPNYPSI
QNLTTNATPT STQLQQQQQQ EHLAAMAAAH VSLLQSSRQN QGAPSGNLSN GGDCESLLPP
PPPTSVSGNT NHTGSNSSSN SGSNNHIASP HYMQSRDENF KLTQLKRSFE PDLSGKNPQK
EKDFGYPSAS SASKLPTHNV QQQHANKKPS PLRNYHQQQQ PPYNLTPKYN GPQTPPTPQS
PLAANPHQML SPTMDYNQLH LHHQLNSSSG GSYQHMQQDQ TQSQSHPQHL HYHNQHATSQ
TAPPPLLPPL LTSGQFHAQP QDASQQQTAS SSQHQTHHSR TAQLTNLDQA VKHKPESEEQ
PVITDLSYRN SETDKTAANP VPEAPESPYL TTSNEESLES NSNSSNSRKR RKRKASMVMR
VTPNENAPEG ENSKPQHPQQ AANLNNSCSP KKSPKNGGGE FQPFSTQKQS QTENEKTTQE
NGRGGSPAPA ENNSNSNSST LYNDNENPKT KKQRQALLQR NLTEQHRMQQ DDEPPKNHTS
PAMPPPSPQS NSSSSSSSSS SANTHSSQSS HAVNNIPKPE INNKATTDTP ASPALVEQGD
IDAKPAVSVH ECDEEEEPAV NKVSPAHPDP PTTAAVAAPP ATESPKKSSP AANSESCPFG
EVEDKLEQMF AGIEEETERI SSPEKPAEES AAMVAHNLTA QLALDPSKTL DTPAENQTSV
LAVLAPNQTP TPEIRPVATK AAMKSTMPSP VHSPIPQSRS TSTPLVAGDD SKSNTPVPAK
APAPRRPPPR RLSMGMDASL LRFMIDDPPA KKPGRKKKVT KEPDFEDDDK PSTSAAAAAA
LAARQLSEAA SATKSKPAAG AKKKNAGVKG KKGSAGKGNA KNAKQNGKKS ARKPAFTTDE
DSTPAPTNGG GSVPELRFKS PFILIKPDGS VSIKNTHSAE DVNEKQTKVK KAPHERKNLR
GMHSSTLSNR YDADTTDSTW ICVFCKRGPH KLGLGDLFGP YLVTSDCDEY RAAVQTPGAQ
DIDGMFVNKR RREDMVKGQE RNLPAVPATL ANIMQAPKIS MHKRKRKQTH DSSISYSDDP
NESRSQCSSV DLLDCSTESK FVETFRGMGK TSENGFEVWL HEDCAVWSND IHLIGAHVNG
LDAAVWDSTR YQCVLCQQTG ASICCFQRCC KAAAHVPCGR SANWSLSEED RKVYCHLHRH
EPGVVEPIKT ESIAPVEVSV ATPPAPAPPP AFNIHSLP
