ID   CAS5_ARCFU              Reviewed;         228 AA.
AC   O30169;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=CRISPR-associated protein Cas5;
GN   Name=cas5; OrderedLocusNames=AF_0067;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000782; AAB91170.1; -; Genomic_DNA.
DR   PIR; C69258; C69258.
DR   RefSeq; WP_010877581.1; NC_000917.1.
DR   AlphaFoldDB; O30169; -.
DR   STRING; 224325.AF_0067; -.
DR   EnsemblBacteria; AAB91170; AAB91170; AF_0067.
DR   GeneID; 24793619; -.
DR   KEGG; afu:AF_0067; -.
DR   eggNOG; arCOG02672; Archaea.
DR   HOGENOM; CLU_1232816_0_0_2; -.
DR   OMA; EQINPYS; -.
DR   OrthoDB; 79260at2157; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR   TIGRFAMs; TIGR02593; CRISPR_cas5; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..228
FT                   /note="CRISPR-associated protein Cas5"
FT                   /id="PRO_0000127820"
SQ   SEQUENCE   228 AA;  26199 MW;  CCBAB14B63F07C68 CRC64;
     MQWVKLTLHF PSFFSYRIPD YSSQYALSVP LPSPSAIKLS LVATAIRTTG NVAEGERVFY
     AVRDADIRIL PPEQIAINSV LIKRLKKKKN PTELETFEKT FGVREYVFFP DDVNLFIGCD
     DIDIAIKYFG MLRYLGSSDS MLYVKCIEKI NEPPKSAIKA IADKEFAEAI SKEPYIVYPV
     KDISKKAKFE QINPYSGKSG RNVFERKYYL IKARIKKGKK WKLLEIQC