ID   Y510_ARCFU              Reviewed;         289 AA.
AC   O29740;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Uncharacterized transporter AF_0510;
GN   OrderedLocusNames=AF_0510;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EamA transporter family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90720.1; -; Genomic_DNA.
DR   PIR; F69313; F69313.
DR   RefSeq; WP_010878017.1; NC_000917.1.
DR   AlphaFoldDB; O29740; -.
DR   SMR; O29740; -.
DR   STRING; 224325.AF_0510; -.
DR   TCDB; 2.A.7.3.36; the drug/metabolite transporter (dmt) superfamily.
DR   EnsemblBacteria; AAB90720; AAB90720; AF_0510.
DR   GeneID; 24794050; -.
DR   KEGG; afu:AF_0510; -.
DR   eggNOG; arCOG00271; Archaea.
DR   HOGENOM; CLU_033863_21_3_2; -.
DR   OMA; WSINAVV; -.
DR   OrthoDB; 47457at2157; -.
DR   PhylomeDB; O29740; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000620; EamA_dom.
DR   Pfam; PF00892; EamA; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..289
FT                   /note="Uncharacterized transporter AF_0510"
FT                   /id="PRO_0000108202"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..136
FT                   /note="EamA 1"
FT   DOMAIN          159..285
FT                   /note="EamA 2"
SQ   SEQUENCE   289 AA;  31845 MW;  88BAC453FFBEB705 CRC64;
     MNSKTHLLLA LTMLIWAGSF IFIKIGLKEL DPFNLAFYRF LLASPLLMAW VFWKRGLAKP
     SGSEWLHLSV LALSGVTLLY AFQFLALKYT TATNASILIN TSAVFVALWG LVKGEANPRK
     LAGVFLSFAG VVLIVSKGTL EFFSSKTIFG DVLMIVDGFL WAVYTVLGSK MLLKYDHETL
     TAYAFALGTI FLIPFALMSG FANPVTFNPE TVAALLYLSI LCSVFAYVVW YYALTNADST
     SVAVYVYLVP LFTAIFAFYA LNEKPDFFTA IGGIITIAGV YLTTAKQHQ