ID   Y5122_MYCSJ             Reviewed;         314 AA.
AC   A3Q6V9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase Mjls_5122;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Mjls_5122;
OS   Mycobacterium sp. (strain JLS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=164757;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Anderson A.J.,
RA   Sims R.C., Richardson P.;
RT   "Complete sequence of Mycobacterium sp. JLS.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; CP000580; ABO00887.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3Q6V9; -.
DR   SMR; A3Q6V9; -.
DR   STRING; 164757.Mjls_5122; -.
DR   KEGG; mjl:Mjls_5122; -.
DR   HOGENOM; CLU_021322_0_0_11; -.
DR   OMA; QVPPYEY; -.
DR   BioCyc; MSP164757:G1G8C-5172-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..314
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase
FT                   Mjls_5122"
FT                   /id="PRO_0000379578"
FT   REGION          1..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         266
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         286
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         295
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  32641 MW;  B3F287DFE5E379E1 CRC64;
     MAGNSKRRGA VRKAGTKKGP TVGSGGVRRR GLEGRGATPP AHQRPNHPAA KRAAKAAKQQ
     QRRPARKTDE TELVLGRNPV VECLRAEVPA TALYVAMGTE ADERVTEAVQ IAADSGISIL
     EVPRSDLDRM SNNALHQGLG LQVPPYDYAH PDDLLATAKA DGAPALLVAL DNISDPRNLG
     AIVRSVAAFG GHGVLIPQRR SASVTAVAWR TSAGAAARLP VARATNLNRT LKSWADGGLQ
     VVGLDADGDT TLDELDGTGP VVVVVGSEGK GLSRLVRENC DAVVSIPMAG PTESLNASVA
     AGVVLAEIAR QRRS