ID   CAS5_METJA              Reviewed;         245 AA.
AC   Q57827;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=CRISPR-associated protein Cas5;
GN   Name=cas5; OrderedLocusNames=MJ0382;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC       Subtype I-A/Apern subfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98378.1; -; Genomic_DNA.
DR   PIR; F64347; F64347.
DR   AlphaFoldDB; Q57827; -.
DR   STRING; 243232.MJ_0382; -.
DR   EnsemblBacteria; AAB98378; AAB98378; MJ_0382.
DR   KEGG; mja:MJ_0382; -.
DR   eggNOG; arCOG02672; Archaea.
DR   HOGENOM; CLU_1056094_0_0_2; -.
DR   OMA; MRREYTF; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:InterPro.
DR   InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR   InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR   InterPro; IPR010153; CRISPR-assoc_prot_Cas5a-typ.
DR   Pfam; PF09704; Cas_Cas5d; 1.
DR   TIGRFAMs; TIGR01874; cas_cas5a; 1.
DR   TIGRFAMs; TIGR02593; CRISPR_cas5; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..245
FT                   /note="CRISPR-associated protein Cas5"
FT                   /id="PRO_0000106845"
SQ   SEQUENCE   245 AA;  28255 MW;  6169A4FFC51AE8BA CRC64;
     MIMEALVALL RFPFYSFGKQ SYQVRQSLLL PSPSALKGAL AKGIILLGGK KGKSLDEIAK
     KTVEELENKL IYVGAKPYKS SIIKTPILLK RLRNLEDQKN PEKSDAMRRE YVFAREILAI
     YVFRRKLSEE EKDLMLKAVY LIDQLGDTEC VGNVIKTEWV EVKEEKAPLK TYVKFKKVSK
     MSINGGIIEN MLETPNFGNK VKEEPYLLPL IEKRYRRSSY YVESDRIFDG NYKIIAFDEV
     IGLWI