CAS5_THETK
ID CAS5_THETK Reviewed; 226 AA.
AC G4RJZ2;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=CRISPR-associated protein Cas5;
GN Name=cas5a; OrderedLocusNames=TTX_1252;
OS Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS / Kra 1).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Thermoproteus.
OX NCBI_TaxID=768679;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA Hensel R.;
RT "The complete genome sequence of Thermoproteus tenax: a physiologically
RT versatile member of the Crenarchaeota.";
RL PLoS ONE 6:E24222-E24222(2011).
RN [2]
RP SUBUNIT, INDUCTION, AND OPERON STRUCTURE.
RC STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX PubMed=22408157; DOI=10.1128/jb.00206-12;
RA Plagens A., Tjaden B., Hagemann A., Randau L., Hensel R.;
RT "Characterization of the CRISPR/Cas subtype I-A system of the
RT hyperthermophilic crenarchaeon Thermoproteus tenax.";
RL J. Bacteriol. 194:2491-2500(2012).
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat) is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Can form a Cascade complex with Csa5, Cas7, Cas3, Cas3' and
CC Cas8a2. {ECO:0000269|PubMed:22408157}.
CC -!- INDUCTION: Repressed by 5 J/m2 ultraviolet light and 50 mM NaCl,
CC slightly induced by 20 J/m2 ultraviolet light, 100 and 150 mM Nacl.
CC Member of the csa5-cas7-cas5a-cas3-cas3'-cas8a2 operon.
CC {ECO:0000269|PubMed:22408157}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC Subtype I-A/Apern subfamily. {ECO:0000305}.
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DR EMBL; FN869859; CCC81887.1; -; Genomic_DNA.
DR RefSeq; WP_014127142.1; NC_016070.1.
DR AlphaFoldDB; G4RJZ2; -.
DR STRING; 768679.TTX_1252; -.
DR EnsemblBacteria; CCC81887; CCC81887; TTX_1252.
DR GeneID; 11262132; -.
DR KEGG; ttn:TTX_1252; -.
DR PATRIC; fig|768679.9.peg.1265; -.
DR eggNOG; arCOG02672; Archaea.
DR HOGENOM; CLU_1212637_0_0_2; -.
DR OMA; YQVASAY; -.
DR Proteomes; UP000002654; Chromosome.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:InterPro.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR010153; CRISPR-assoc_prot_Cas5a-typ.
DR Pfam; PF09704; Cas_Cas5d; 1.
DR TIGRFAMs; TIGR01874; cas_cas5a; 1.
DR TIGRFAMs; TIGR02593; CRISPR_cas5; 1.
PE 1: Evidence at protein level;
KW Antiviral defense; Reference proteome.
FT CHAIN 1..226
FT /note="CRISPR-associated protein Cas5"
FT /id="PRO_0000422227"
SQ SEQUENCE 226 AA; 24530 MW; 7BABF3A3A440F28F CRC64;
MHYYLIEARA PLYSVKVVDV YQVASAYPLP TPHAVVGALG AAMAHAGMCR GLQCMKEAEG
LVVAARPAAV GELAKFPAVL WRTRGVLEDK SLPAGLEDYA GARDAMVREY VYAHAVKILL
VTRKRVPQHV IRLMARLGDS ESYVSVVDVL EGKPRECGGL VNVAVRAAKA RRGSYTLYRA
LDERGNRELF AYPVVEEGGV YRRGGVEVGS KVLCLGEAVF PEGDGW
