ID   Y519_HAEIN              Reviewed;         417 AA.
AC   P44742;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Uncharacterized transporter HI_0519;
GN   OrderedLocusNames=HI_0519;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC       (TC 2.A.41) family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22177.1; -; Genomic_DNA.
DR   PIR; A64154; A64154.
DR   RefSeq; NP_438677.1; NC_000907.1.
DR   RefSeq; WP_005649475.1; NC_000907.1.
DR   AlphaFoldDB; P44742; -.
DR   SMR; P44742; -.
DR   STRING; 71421.HI_0519; -.
DR   EnsemblBacteria; AAC22177; AAC22177; HI_0519.
DR   KEGG; hin:HI_0519; -.
DR   PATRIC; fig|71421.8.peg.538; -.
DR   eggNOG; COG1972; Bacteria.
DR   HOGENOM; CLU_016813_4_2_6; -.
DR   OMA; IVWHTVI; -.
DR   PhylomeDB; P44742; -.
DR   BioCyc; HINF71421:G1GJ1-532-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IBA:GO_Central.
DR   GO; GO:1901642; P:nucleoside transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR008276; C_nuclsd_transpt.
DR   InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR   InterPro; IPR011657; CNT_C_dom.
DR   InterPro; IPR002668; CNT_N_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   PANTHER; PTHR10590; PTHR10590; 1.
DR   Pfam; PF07670; Gate; 1.
DR   Pfam; PF07662; Nucleos_tra2_C; 1.
DR   Pfam; PF01773; Nucleos_tra2_N; 1.
DR   TIGRFAMs; TIGR00804; nupC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..417
FT                   /note="Uncharacterized transporter HI_0519"
FT                   /id="PRO_0000070459"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  42773 MW;  9075BFCFE7FC20A6 CRC64;
     MSVLSSILGM VVLIAIAVLL SNNRKAISIR TVVGALAIQV GFAALILYVP AGKQALGAAA
     DMVSNVIAYG NDGINFVFGG LADPSKPSGF IFAVKVLPII VFFSGLISVL YYLGIMQVVI
     KVLGGALQKA LGTSKAESMS AAANIFVGQT EAPLVVRPYI KNMTQSELFA IMVGGTASIA
     GSVMAGYAGM GVPLTYLIAA SFMAAPAGLL FAKLMFPQTE QFTDKQPEDN DSEKPTNVLE
     AMAGGASAGM QLALNVGAML IAFVGLIALI NGILSGVGGW FGYGDLTLQS IFGLIFKPLA
     YLIGVTDGAE AGIAGQMIGM KLAVNEFVGY LEFAKYLQPD SAIVLTEKTK AIITFALCGF
     ANFSSIAILI GGLGGMAPSR RSDVARLGIK AVIAGTLANL MSATIAGLFI GLGAAAL