ID   Y5204_STRCO             Reviewed;        1000 AA.
AC   Q9FCI4; Q9K4B4;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=UPF0182 protein SCO5204 {ECO:0000255|HAMAP-Rule:MF_01600};
GN   OrderedLocusNames=SCO5204; ORFNames=2SC3B6.28, SC7E4.01;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
CC   -!- SIMILARITY: Belongs to the UPF0182 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01600}.
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DR   EMBL; AL939122; CAD55225.1; -; Genomic_DNA.
DR   RefSeq; NP_733657.1; NC_003888.3.
DR   RefSeq; WP_003973771.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; Q9FCI4; -.
DR   SMR; Q9FCI4; -.
DR   STRING; 100226.SCO5204; -.
DR   GeneID; 1100645; -.
DR   KEGG; sco:SCO5204; -.
DR   PATRIC; fig|100226.15.peg.5287; -.
DR   eggNOG; COG1615; Bacteria.
DR   HOGENOM; CLU_007733_1_0_11; -.
DR   InParanoid; Q9FCI4; -.
DR   OMA; HLRYPQD; -.
DR   PhylomeDB; Q9FCI4; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_01600; UPF0182; 1.
DR   InterPro; IPR005372; UPF0182.
DR   PANTHER; PTHR39344; PTHR39344; 1.
DR   Pfam; PF03699; UPF0182; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1000
FT                   /note="UPF0182 protein SCO5204"
FT                   /id="PRO_0000157728"
FT   TRANSMEM        26..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        70..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        177..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        220..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        267..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   TRANSMEM        296..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01600"
FT   REGION          884..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          943..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        965..979
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1000 AA;  109555 MW;  C30AB3349CA9E410 CRC64;
     MPDRGGGPPT GPRIRVGRPS RRVRTLLLTL GVLAVLAMAF TMFAGFWTDW LWYRSVHYSS
     VFTTTLWTKI GLFFVFGLLM ALAVGFNIWL AHRLRPPLSA MSMEQQNLDR YRMGIAPYKK
     WLLLGITALV GLIAGASASG QWRTWLMWVN GVPFGQKDPQ FKLDVSFYAF DLPWYRFLLG
     FGFAAVIISV IAAALTHYLY GGLRVTSPGA RATAAATGHL SVLLGVFVAL KAVAYWLDRY
     GLAVKSSDFK ATDNWTGLRY VDANAYLPAK TILFCIAVIC ALLFFATLWR RTWQLPVIGF
     GLMVLSAILI GGLYPALVQK FQVQPNEQAK EAPYVEKNLA ATRDAYGIEG TQVAEYPGKS
     ETKDKTKLRD DADAAASVRI MDPNIISPTF QQLQQMRNYY AFPTNLDVDR YAKDGKDQDT
     VIGLRELNLA GIPKKNWINN HFRYTHGYGV VAAKGTQVDS EGRPVFTESN LPSEGDLGKY
     EQRIYYGEKT TTYSIVGGPQ KEIDYSDDTG EKTFSYKGDG GVDLSNPINR AAYAAAFSEP
     QILYSGAIGD GSRILYNRTP KERVEAVAPW LTIDGDAYPA VVDGRIQWIV DAYTTTNGYP
     YASRTTLGDT TADSLTANNN SRAVVAQQNQ VNYIRNSVKA TVDAYSGDVK LYEWDTQDPV
     LKTWKKAFPG TVQDKGEISK ELMAHLRYPQ DLFKVQRELL TRYHVKDANT FLSGSEVWQV
     PDDPTNKSGD AVPPYYLSMK MPDQKAQAFS LTTTFTPNGR DNLSAFMAVD AEAGTSDYGK
     IRILKLPTST TVDGPKQVQS QFNSEQDIAE SIRLLRGGDS EVEYGNLLTV PLDGGLLYVE
     PVYVRGGDLK YPLLRKVLVS YGGNTAFENT LDAALNKVFG AQAAETEQPP DEGDDTTEPP
     PTSTNPTVRE ALSDAQKAFD AGQKALEQKD LAAYAEAQKD LEEALQRAED AQAKADQGAG
     GKNGDDKNAG DKNSGDKAGS DKAGPDATPT GDAGGGADTG