ID   CAS6_MYCTO              Reviewed;         314 AA.
AC   P9WPJ0; F2GLB0; L0TCC6; P71628; Q7D6I1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=CRISPR-associated endoribonuclease Cas6;
DE            EC=3.1.-.-;
GN   Name=cas6; OrderedLocusNames=MT2891;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain sequences complementary to
CC       antecedent mobile elements and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA).
CC       Processes pre-crRNA into individual crRNA units.
CC       {ECO:0000250|UniProtKB:P9WPJ1}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250|UniProtKB:P9WPJ1};
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE
CC       family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47216.1; -; Genomic_DNA.
DR   PIR; C70692; C70692.
DR   RefSeq; WP_003899496.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WPJ0; -.
DR   SMR; P9WPJ0; -.
DR   EnsemblBacteria; AAK47216; AAK47216; MT2891.
DR   KEGG; mtc:MT2891; -.
DR   PATRIC; fig|83331.31.peg.3120; -.
DR   HOGENOM; CLU_063836_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR019267; CRISPR-assoc_Cas6_C.
DR   InterPro; IPR010156; CRISPR-assoc_prot_Cas6.
DR   Pfam; PF10040; CRISPR_Cas6; 1.
DR   TIGRFAMs; TIGR01877; cas_cas6; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Endonuclease; Hydrolase; Nuclease; RNA-binding.
FT   CHAIN           1..314
FT                   /note="CRISPR-associated endoribonuclease Cas6"
FT                   /id="PRO_0000426943"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34432 MW;  0351BF2BA94419D2 CRC64;
     MAARRGGIRR TDLLRRSGQP RGRHRASAAE SGLTWISPTL ILVGFSHRGD RRMTEHLSRL
     TLTLEVDAPL ERARVATLGP HLHGVLMESI PADYVQTLHT VPVNPYSQYA LARSTTSLEW
     KISTLTNEAR QQIVGPINDA AFAGFRLRAS GIATQVTSRS LEQNPLSQFA RIFYARPETR
     KFRVEFLTPT AFKQSGEYVF WPDPRLVFQS LAQKYGAIVD GEEPDPGLIA EFGQSVRLSA
     FRVASAPFAV GAARVPGFTG SATFTVRGVD TFASYIAALL WFGEFSGCGI KASMGMGAIR
     VQPLAPREKC VPKP