ID   Y522_TREPA              Reviewed;         159 AA.
AC   O83534;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Uncharacterized protein TP_0522;
GN   OrderedLocusNames=TP_0522;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000520; AAC65511.1; -; Genomic_DNA.
DR   PIR; H71315; H71315.
DR   RefSeq; WP_010881970.1; NC_021490.2.
DR   AlphaFoldDB; O83534; -.
DR   IntAct; O83534; 1.
DR   STRING; 243276.TPANIC_0522; -.
DR   EnsemblBacteria; AAC65511; AAC65511; TP_0522.
DR   GeneID; 57879045; -.
DR   KEGG; tpa:TP_0522; -.
DR   eggNOG; COG1286; Bacteria.
DR   HOGENOM; CLU_129914_0_0_12; -.
DR   OMA; FFLVIHI; -.
DR   OrthoDB; 2061122at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009403; P:toxin biosynthetic process; IEA:InterPro.
DR   InterPro; IPR003825; Colicin-V_CvpA.
DR   Pfam; PF02674; Colicin_V; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..159
FT                   /note="Uncharacterized protein TP_0522"
FT                   /id="PRO_0000202269"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  17810 MW;  A922297C1E507CF1 CRC64;
     MTISTLDLIL GIIMGIVTVR ATMRGFVDEF FSKASILCAA VVAILCHKRL VPLTRVLLGH
     SILLPCITFL ITFMGVYCVM LFLRSRMRTY ATRDLISGFN QVFGFFFGII EGSVLLTVIL
     LLLHVQPFVS VSHMLHESVI NTVLSPLVLD GVRYMRLKM