ID   Y5281_DICDI             Reviewed;         216 AA.
AC   Q54ST6; Q54ST7;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=ER membrane protein complex subunit 7 homolog;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0282229;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the EMC7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL66320.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAL66321.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000046; EAL66321.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAFI02000046; EAL66320.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_640298.1; XM_635206.1.
DR   RefSeq; XP_640299.1; XM_635207.1.
DR   AlphaFoldDB; Q54ST6; -.
DR   SMR; Q54ST6; -.
DR   STRING; 44689.DDB0205280; -.
DR   PaxDb; Q54ST6; -.
DR   EnsemblProtists; EAL66320; EAL66320; DDB_G0282229.
DR   EnsemblProtists; EAL66321; EAL66321; DDB_G0282231.
DR   GeneID; 8623474; -.
DR   GeneID; 8623475; -.
DR   KEGG; ddi:DDB_G0282229; -.
DR   KEGG; ddi:DDB_G0282231; -.
DR   dictyBase; DDB_G0282229; -.
DR   eggNOG; ENOG502RHYG; Eukaryota.
DR   InParanoid; Q54ST6; -.
DR   PhylomeDB; Q54ST6; -.
DR   PRO; PR:Q54ST6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR   InterPro; IPR039163; EMC7.
DR   InterPro; IPR019008; EMC7_beta_sandwich.
DR   PANTHER; PTHR13605; PTHR13605; 1.
DR   Pfam; PF09430; DUF2012; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..216
FT                   /note="ER membrane protein complex subunit 7 homolog"
FT                   /id="PRO_0000351247"
FT   TOPO_DOM        22..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..216
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   216 AA;  24821 MW;  16B9DF03689BDB6A CRC64;
     MKSNVFILIF ILFSIINLSF ANEQTKKPQQ PQQQQQTTSP VNKLEAKLFA PNDAKFSSYR
     VKLRDINTFN EIVQIPTKDG IFSFVNMSNG LYSLEIESMQ YNFPHFKVDV LGKNKIKVRP
     AENETSILPL PLQIKATHRI PFFQQHVPFS IFSLVQNPMA ISVLFTCALI FLLPKMMSFI
     EQDEETKEAL KASTPALVQQ LPEWPTITQK QLENKE