ID   Y5308_MYCS2             Reviewed;         368 AA.
AC   A0R316;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Seven-bladed beta-propeller protein MSMEG_5308 {ECO:0000303|PubMed:31239378};
GN   OrderedLocusNames=MSMEG_5308 {ECO:0000303|PubMed:31239378,
GN   ECO:0000312|EMBL:ABK75599.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196 {ECO:0000312|EMBL:ABK75599.1};
RN   [1] {ECO:0000312|EMBL:ABK75599.1, ECO:0000312|Proteomes:UP000000757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000312|Proteomes:UP000000757};
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INTERACTION WITH MMPL3 AND TTFA, SUBCELLULAR LOCATION,
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700084 / mc(2)155 {ECO:0000303|PubMed:31239378};
RX   PubMed=31239378; DOI=10.1128/mbio.00850-19;
RA   Fay A., Czudnochowski N., Rock J.M., Johnson J.R., Krogan N.J.,
RA   Rosenberg O., Glickman M.S.;
RT   "Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in
RT   Mycobacteria.";
RL   MBio 10:E00850-E00850(2019).
CC   -!- FUNCTION: Stabilizes the MmpL3/TtfA trehalose monomycolate (TMM)
CC       transport complex under stress conditions.
CC       {ECO:0000269|PubMed:31239378}.
CC   -!- SUBUNIT: Interacts with MmpL3 and TtfA. {ECO:0000269|PubMed:31239378}.
CC   -!- SUBCELLULAR LOCATION: Cell septum {ECO:0000269|PubMed:31239378}. Cell
CC       tip {ECO:0000269|PubMed:31239378}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:31239378}.
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DR   EMBL; CP000480; ABK75599.1; -; Genomic_DNA.
DR   RefSeq; YP_889554.1; NC_008596.1.
DR   AlphaFoldDB; A0R316; -.
DR   SMR; A0R316; -.
DR   STRING; 246196.MSMEI_5165; -.
DR   PRIDE; A0R316; -.
DR   EnsemblBacteria; ABK75599; ABK75599; MSMEG_5308.
DR   KEGG; msm:MSMEG_5308; -.
DR   PATRIC; fig|246196.19.peg.5178; -.
DR   eggNOG; COG3391; Bacteria.
DR   OMA; YVASCGP; -.
DR   Proteomes; UP000000757; Chromosome.
DR   GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR   GO; GO:0051286; C:cell tip; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   SUPFAM; SSF50969; SSF50969; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..368
FT                   /note="Seven-bladed beta-propeller protein MSMEG_5308"
FT                   /id="PRO_0000452602"
SQ   SEQUENCE   368 AA;  38249 MW;  7FF2E0D342F0942F CRC64;
     MTMAKNILRA ITAIVRRDAK TPDTDDSAGS VTFDGALDDL DVAGLVEVGR GPIADIAIDA
     DRETIVVTNS AADCLTVINP YTLAPVGSVR LNGEPFAVAA ADDRAYVSVV TAGHDAIKVV
     DTITGSVLAE YPLAMTVTAL AMSPDGKRVF VGRSGHDRID VAVIDTAAER VGTIDLASGA
     GAGVDALRVD ASGKRLYVAT TDPRGSRMVT VNIETAQIES TVWIGAPIRD LALGADGKAL
     VLTSDRQRRG VVHIVDLSTA AVVGAIQIGG APTQLVLSPD ATRAYVVDYD RVIVLCTLTN
     EILGSIDVGM QPAAVAVRRD GARVYVADYS GQVNAFDVAA ELPALYSRLV ASEPRQDATT
     VLPSLQTA