ID   CAS7_METJA              Reviewed;         320 AA.
AC   Q57826;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=CRISPR-associated protein Cas7/Cst2/DevR;
DE   AltName: Full=CRISPR-associated protein Cas7/Csa2, subtype I-A/Apern;
GN   Name=cas7; OrderedLocusNames=MJ0381;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas7/Cst2/DevR
CC       family. Subtype I-a/Apern subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB98370.1; -; Genomic_DNA.
DR   PIR; E64347; E64347.
DR   RefSeq; WP_010869880.1; NC_000909.1.
DR   AlphaFoldDB; Q57826; -.
DR   SMR; Q57826; -.
DR   STRING; 243232.MJ_0381; -.
DR   PRIDE; Q57826; -.
DR   EnsemblBacteria; AAB98370; AAB98370; MJ_0381.
DR   GeneID; 1451238; -.
DR   KEGG; mja:MJ_0381; -.
DR   eggNOG; arCOG03617; Archaea.
DR   HOGENOM; CLU_054331_1_0_2; -.
DR   InParanoid; Q57826; -.
DR   OMA; MIYYVET; -.
DR   OrthoDB; 47264at2157; -.
DR   PhylomeDB; Q57826; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR002764; Cas7/Cst2/DevR_sub_I-a/Apern.
DR   InterPro; IPR010154; CRISPR-assoc_Cas7/Cst2/DevR.
DR   Pfam; PF01905; DevR; 1.
DR   TIGRFAMs; TIGR01875; cas_MJ0381; 1.
DR   TIGRFAMs; TIGR02583; DevR_archaea; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..320
FT                   /note="CRISPR-associated protein Cas7/Cst2/DevR"
FT                   /id="PRO_0000106844"
SQ   SEQUENCE   320 AA;  35924 MW;  81CA8DE178F4B223 CRC64;
     MFLRISGRVR LNSHSLNAQG GGGTNYVEIT KAKVSIKNDD RWEILEVPAI SGNMVKHWHF
     VSFVDFFRET DYKDNLTERA LRYNGARFGQ ETKAKKADGS EVELKDESEI IKNFADADVH
     GFLAPKTGVR RVSLVKTSFI LPTEDFIKEV DERLVYAVKH NRVDIDEKGA IKSGEEQTAQ
     MLFNREYATG LYGFEIILDL GFVGVPQSSP SNPVIEDDER KARIVSALKA LIPMLSGYIG
     ANLARSFPVF KLEEMIAVVS EKPIPALVHG FYEDYVEVSK NVVENAKKLG FEIEDFGYNV
     DFGESVSSVE ELISKIIEKL