ID   CAS7_THETK              Reviewed;         329 AA.
AC   G4RJZ1;
DT   01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=CRISPR-associated protein Cas7/Cst2/DevR;
DE   AltName: Full=CRISPR-associated protein Cas7/Csa2, subtype I-A/Apern;
GN   Name=cas7; OrderedLocusNames=TTX_1251;
OS   Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435
OS   / Kra 1).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Thermoproteus.
OX   NCBI_TaxID=768679;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22003381; DOI=10.1371/journal.pone.0024222;
RA   Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D.,
RA   Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M.,
RA   Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C.,
RA   Hensel R.;
RT   "The complete genome sequence of Thermoproteus tenax: a physiologically
RT   versatile member of the Crenarchaeota.";
RL   PLoS ONE 6:E24222-E24222(2011).
RN   [2]
RP   SUBUNIT, INDUCTION, AND OPERON STRUCTURE.
RC   STRAIN=ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1;
RX   PubMed=22408157; DOI=10.1128/jb.00206-12;
RA   Plagens A., Tjaden B., Hagemann A., Randau L., Hensel R.;
RT   "Characterization of the CRISPR/Cas subtype I-A system of the
RT   hyperthermophilic crenarchaeon Thermoproteus tenax.";
RL   J. Bacteriol. 194:2491-2500(2012).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Can form a Cascade complex with Csa5, Cas5a, Cas3, Cas3' and
CC       Cas8a2. {ECO:0000269|PubMed:22408157}.
CC   -!- INDUCTION: Repressed by 5 J/m2 ultraviolet light and 50 mM NaCl,
CC       slightly induced by 20 J/m2 ultraviolet light, 100 and 150 mM Nacl.
CC       Member of the csa5-cas7-cas5a-cas3-cas3'-cas8a2 operon.
CC       {ECO:0000269|PubMed:22408157}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas7/Cst2/DevR
CC       family. Subtype I-a/Apern subfamily. {ECO:0000305}.
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DR   EMBL; FN869859; CCC81886.1; -; Genomic_DNA.
DR   RefSeq; WP_014127141.1; NC_016070.1.
DR   AlphaFoldDB; G4RJZ1; -.
DR   SMR; G4RJZ1; -.
DR   STRING; 768679.TTX_1251; -.
DR   EnsemblBacteria; CCC81886; CCC81886; TTX_1251.
DR   GeneID; 11262131; -.
DR   KEGG; ttn:TTX_1251; -.
DR   PATRIC; fig|768679.9.peg.1264; -.
DR   eggNOG; arCOG03617; Archaea.
DR   HOGENOM; CLU_054331_1_0_2; -.
DR   OMA; MIYYVET; -.
DR   OrthoDB; 47264at2157; -.
DR   Proteomes; UP000002654; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR002764; Cas7/Cst2/DevR_sub_I-a/Apern.
DR   InterPro; IPR010154; CRISPR-assoc_Cas7/Cst2/DevR.
DR   Pfam; PF01905; DevR; 1.
DR   TIGRFAMs; TIGR01875; cas_MJ0381; 1.
DR   TIGRFAMs; TIGR02583; DevR_archaea; 1.
PE   1: Evidence at protein level;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..329
FT                   /note="CRISPR-associated protein Cas7/Cst2/DevR"
FT                   /id="PRO_0000422236"
SQ   SEQUENCE   329 AA;  35903 MW;  8A4143EB24970CB7 CRC64;
     MRVAPPYVRA AGRFEAQLSV LTGAGNMGNY NMHAVAKVIH GGKAYEVPVL TGNALKHWHS
     VYLAEVYQDL GGTQLNEFCK KGVGLRGKNM SGEDASSEAE AIKDLCNDLH GFLLPDKQIK
     RDSLVRVSFA VPVLEEKNLE AASKFAVVHN RVDPFKRTQQ VKSKEEQEGT EMMVFKQEYS
     SAVYGFAAAM DLGLSGVPLY QEGESGVDDR ERALRIKSAL VALLRLFNGV GSKQARALPI
     ARLRELVIAI SDSPIPNLVH GAYPDYVARS AELLTAYLKA VGKKGVVLCY GVDCPQSNNV
     LECKKADTLD DLFQEALRRA LPGGQPARR