ID   CAS8A_METJA             Reviewed;         375 AA.
AC   Q57830;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=CRISPR-associated protein Cas8a2/Csa4;
DE   AltName: Full=CRISPR-associated protein Cas8a2/Csa4, subtype I-A/Apern;
GN   Name=cas8a2; OrderedLocusNames=MJ0385;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas8a2/Csa4
CC       family. Subtype I-A/Apern subfamily. {ECO:0000305}.
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DR   EMBL; L77117; AAB98380.1; -; Genomic_DNA.
DR   PIR; A64348; A64348.
DR   AlphaFoldDB; Q57830; -.
DR   STRING; 243232.MJ_0385; -.
DR   EnsemblBacteria; AAB98380; AAB98380; MJ_0385.
DR   KEGG; mja:MJ_0385; -.
DR   eggNOG; arCOG01441; Archaea.
DR   HOGENOM; CLU_722832_0_0_2; -.
DR   InParanoid; Q57830; -.
DR   OMA; KLMDFLW; -.
DR   PhylomeDB; Q57830; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd09666; Cas8a2_I-A; 1.
DR   InterPro; IPR010184; CRISPR-assoc_prot_MJ0385.
DR   Pfam; PF09703; Cas_Csa4; 1.
DR   TIGRFAMs; TIGR01914; cas_Csa4; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome.
FT   CHAIN           1..375
FT                   /note="CRISPR-associated protein Cas8a2/Csa4"
FT                   /id="PRO_0000106848"
SQ   SEQUENCE   375 AA;  43187 MW;  9A2853EA2CBEBE51 CRC64;
     MIIKGLRVEK EKLQSLQKFW RLRVMLFETP GYNEILDLYI AYGVVECLVR EGVENLRFFP
     IGNKYCIVVE EPTNVNIKNR IEKGMLNALE DMLSLHKAIG KYISTKEDIK IISDVDFSAG
     ANINNVYWDG IPKTLEKIKE NIKKGKLSTK SKNTVPLTLM PAAGKYMPKI YGVKGGNPIK
     IDDSNYALAW IGFHYYAPYI NISDNRATYI HIYAIKPLEE LGLIEILALK DLKKKINNYQ
     LGKYKFFVNK KLALLYHLTH TESISALEIV TKKNFSVVSY TLENVDNNQA IRSFGEYDLS
     KLMDFLWYLK ATDFYNTIQF VDNILRGDLE VSLTFIDGIL YDDLDAVYSA IRKLKSVRIS
     PLIIQSILEW FGNFY