Y532_RICTY
ID Y532_RICTY Reviewed; 242 AA.
AC Q68WJ1;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase RT0532;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=RT0532;
OS Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=257363;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-144 / Wilmington;
RX PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA Yu X.-J., Walker D.H., Weinstock G.M.;
RT "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT of other Rickettsiae.";
RL J. Bacteriol. 186:5842-5855(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RsuA family.
CC {ECO:0000305}.
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DR EMBL; AE017197; AAU04001.1; -; Genomic_DNA.
DR RefSeq; WP_011190982.1; NC_006142.1.
DR AlphaFoldDB; Q68WJ1; -.
DR SMR; Q68WJ1; -.
DR STRING; 257363.RT0532; -.
DR EnsemblBacteria; AAU04001; AAU04001; RT0532.
DR KEGG; rty:RT0532; -.
DR eggNOG; COG1187; Bacteria.
DR HOGENOM; CLU_024979_1_0_5; -.
DR OMA; SMEFAPF; -.
DR OrthoDB; 1037615at2; -.
DR Proteomes; UP000000604; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR Gene3D; 3.30.70.1560; -; 1.
DR Gene3D; 3.30.70.580; -; 1.
DR InterPro; IPR042092; PsdUridine_s_RsuA/RluB/E/F_cat.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR000748; PsdUridine_synth_RsuA/RluB/E/F.
DR InterPro; IPR018496; PsdUridine_synth_RsuA/RluB_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR TIGRFAMs; TIGR00093; TIGR00093; 1.
DR PROSITE; PS01149; PSI_RSU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase; RNA-binding.
FT CHAIN 1..242
FT /note="Uncharacterized RNA pseudouridine synthase RT0532"
FT /id="PRO_0000294477"
FT DOMAIN 2..69
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT ACT_SITE 102
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
SQ SEQUENCE 242 AA; 27756 MW; A422912F78AD4188 CRC64;
MYRLAKIISN AGVCSRRNAE KLIVGGKVKI DGITILSPAT NVDISNQIEV SGRLINNIQK
PRLWIYYKPI GLITTHKDPL SRKTVFEQLI GLPRVISIGR LDLNSEGLLL LTNSGDLAHQ
FEMPSSKLKR VYNVRAYGNA NFLLKNNYNN LKIDGIFYNP YSIKLLRQNK NNSWFEVVLF
EGKNREIRRI FEYFGLKVNK LIRVQYGALK IGNLKPGDYK EISNKILKKI ISNKLTNYID
NR
