ID   Y5337_MYCVP             Reviewed;         314 AA.
AC   A1TG08;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase Mvan_5337;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Mvan_5337;
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; CP000511; ABM16108.1; -; Genomic_DNA.
DR   RefSeq; WP_011782478.1; NC_008726.1.
DR   AlphaFoldDB; A1TG08; -.
DR   SMR; A1TG08; -.
DR   STRING; 350058.Mvan_5337; -.
DR   EnsemblBacteria; ABM16108; ABM16108; Mvan_5337.
DR   KEGG; mva:Mvan_5337; -.
DR   eggNOG; COG0566; Bacteria.
DR   HOGENOM; CLU_021322_0_0_11; -.
DR   OMA; QVPPYEY; -.
DR   OrthoDB; 1422015at2; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..314
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase
FT                   Mvan_5337"
FT                   /id="PRO_0000379584"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..60
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         265
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         285
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         294
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  32520 MW;  D1A600C6FA383E7C CRC64;
     MAGNSQRRGA VRKAGTKKGP TVGSGGVRRR GLEGKGATPP AHQRPHHPAG KRAAKAARQA
     QGRHKKTDDT EIVLGRNPVL ECLRAGVPAT ALYVALGADS DERLTESVQI AADKGIAILE
     VPRHDLDRIA ANGMHQGIAL QVPPYNYAHP DDLLAEAKSD AMPALLVALD NISDPRNLGA
     IVRSVAAFGG HGVLIPQRRS ASVTAVAWRT SAGAAARTPV ARATNLTRAL KQWADAGLQV
     VGLDADGDTT VDQIDGAGPI VVVVGSEGKG LSRLVRENCD AVVSIPMAGP TESLNASVAA
     GVVLAEIARQ RRSA