ID   Y534_METFV              Reviewed;         636 AA.
AC   P56509; E3GYF2;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Uncharacterized protein Mfer_0534;
DE   AltName: Full=ORFD;
GN   OrderedLocusNames=Mfer_0534;
OS   Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=523846;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=21304736; DOI=10.4056/sigs.1283367;
RA   Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S.,
RA   Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Brambilla E., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Sikorski J., Spring S., Rohde M.,
RA   Eichinger K., Huber H., Wirth R., Goker M., Detter J.C., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Complete genome sequence of Methanothermus fervidus type strain (V24S).";
RL   Stand. Genomic Sci. 3:315-324(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 555-636.
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=7506350; DOI=10.1007/bf00277350;
RA   Lehmacher A.;
RT   "Cloning, sequencing and transcript analysis of the gene encoding
RT   formylmethanofuran: tetrahydromethanopterin formyltransferase from the
RT   hyperthermophilic Methanothermus fervidus.";
RL   Mol. Gen. Genet. 242:73-80(1994).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; CP002278; ADP77334.1; -; Genomic_DNA.
DR   EMBL; X70784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_013413612.1; NC_014658.1.
DR   AlphaFoldDB; P56509; -.
DR   SMR; P56509; -.
DR   STRING; 523846.Mfer_0534; -.
DR   EnsemblBacteria; ADP77334; ADP77334; Mfer_0534.
DR   GeneID; 9962258; -.
DR   KEGG; mfv:Mfer_0534; -.
DR   HOGENOM; CLU_430009_0_0_2; -.
DR   OMA; ILKHGCT; -.
DR   OrthoDB; 11337at2157; -.
DR   Proteomes; UP000002315; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 3.30.1340.20; -; 3.
DR   InterPro; IPR035922; 3H_dom_sf.
DR   InterPro; IPR004173; 3H_domain.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02829; 3H; 3.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF75500; SSF75500; 3.
DR   PROSITE; PS51201; RCK_N; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..636
FT                   /note="Uncharacterized protein Mfer_0534"
FT                   /id="PRO_0000066216"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          114..238
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
SQ   SEQUENCE   636 AA;  72388 MW;  E7A9517A9C48CB58 CRC64;
     MDGFYPTNLK NAVIYAALIL ILLFVYGIFG SIYIMHLGVI DAIYYTITTV TTTGFGDIRP
     ITPSQKLFTA SLELIGAGFL LYIFTLMLSV MFMSFSEYVT GAKLKRKIAS MKNHFILCGF
     GRVGSTAFKE LKKRKQKVVI IEKNKDLVET ELWSDPNIIA IPGDATKENV LRYAGIERAK
     CIIIATGSDV DNLFITIEAK ELNPKIWIVA RASERENISR LKKAGANRII SPEFSGGKDI
     YFAAMEPLMM KITVKHGMES IKREAEIIFK HNCTLENIMY HLPEFREPLK RKIEVSDLDH
     IEKFLFQVKK NPRLRESLNK MYESTSGVHS HWISGPSKEN LEKVVEDLKK EGILLGVNLD
     DEKIKEITRK YGMLAEVMVK PEITVVNKHG IDEIRDEAEI ILKHGCTIED IEYYIPGFRE
     PLKRHVGADS IEDIDKFLNT LKKDPKKYDA IDRLYMLSGG GIHSHVISAR SLESLNKVEK
     ELKEKGFLIG VNMSLGEIKE MIQKSGTVVD ILVQHDVKNL EDKKTVVKYG GRILTSKHYL
     PGIRYVLTRK LNLKTMEDVK KCEKELEKPR ARRTLTALYE LSANIHSHTI VTPSAEITKK
     IEEELKEKGI LLGVNFPEEK IWEMVEKEAV EPFCVD