ID   Y535_METJA              Reviewed;         343 AA.
AC   Q57955;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Uncharacterized protein MJ0535;
GN   OrderedLocusNames=MJ0535;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Putative deacetylase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98526.1; -; Genomic_DNA.
DR   PIR; G64366; G64366.
DR   AlphaFoldDB; Q57955; -.
DR   SMR; Q57955; -.
DR   STRING; 243232.MJ_0535; -.
DR   EnsemblBacteria; AAB98526; AAB98526; MJ_0535.
DR   KEGG; mja:MJ_0535; -.
DR   eggNOG; arCOG00324; Archaea.
DR   HOGENOM; CLU_007727_8_2_2; -.
DR   InParanoid; Q57955; -.
DR   OMA; GRAMGFC; -.
DR   PhylomeDB; Q57955; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004407; F:histone deacetylase activity; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..343
FT                   /note="Uncharacterized protein MJ0535"
FT                   /id="PRO_0000114745"
SQ   SEQUENCE   343 AA;  38174 MW;  8848EDB757FDC233 CRC64;
     MVSIMPKILY NPEVLGHKPK SYHVENPERV LTILNSLKSN GFDDIVLIEG KSTINEILEI
     HSRDYVYSII NLSKSFNYYD GDTYLCDRTL DAALTAFKLA KEAVKLALKD RDLYFALTRP
     PGHHAGISGR ALGAMSNGFC IFNNIAGAAR LAKNYMKKVI IIDFDVHHGN GTQEIFWNDN
     RVIHIDFHQR GIYPGTGDIL DIGGEEAKGT KINLPFPAHS TDADYIFAWN EIVEPILNYF
     SPDTVLVSAG FDAFINDGLA SMDLTETFYR FVGAKLSGYS VTAVLEGGYS IGLKYAPPAF
     LDGYVDAKDV LDNLEDYTVI NSNEVKSMVK NVKKIIGEYL DIF