ID   Y536_METFV              Reviewed;         339 AA.
AC   P56510; E3GYF4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=UPF0104 membrane protein Mfer_0536;
DE   AltName: Full=ORFU;
GN   OrderedLocusNames=Mfer_0536;
OS   Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=523846;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=21304736; DOI=10.4056/sigs.1283367;
RA   Anderson I., Djao O.D., Misra M., Chertkov O., Nolan M., Lucas S.,
RA   Lapidus A., Del Rio T.G., Tice H., Cheng J.F., Tapia R., Han C.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Brambilla E., Chen A., Palaniappan K., Land M.,
RA   Hauser L., Chang Y.J., Jeffries C.D., Sikorski J., Spring S., Rohde M.,
RA   Eichinger K., Huber H., Wirth R., Goker M., Detter J.C., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Complete genome sequence of Methanothermus fervidus type strain (V24S).";
RL   Stand. Genomic Sci. 3:315-324(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 226-339.
RC   STRAIN=ATCC 43054 / DSM 2088 / JCM 10308 / V24 S;
RX   PubMed=7506350; DOI=10.1007/bf00277350;
RA   Lehmacher A.;
RT   "Cloning, sequencing and transcript analysis of the gene encoding
RT   formylmethanofuran: tetrahydromethanopterin formyltransferase from the
RT   hyperthermophilic Methanothermus fervidus.";
RL   Mol. Gen. Genet. 242:73-80(1994).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0104 family. {ECO:0000305}.
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DR   EMBL; CP002278; ADP77336.1; -; Genomic_DNA.
DR   EMBL; X70784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_013413614.1; NC_014658.1.
DR   AlphaFoldDB; P56510; -.
DR   STRING; 523846.Mfer_0536; -.
DR   EnsemblBacteria; ADP77336; ADP77336; Mfer_0536.
DR   GeneID; 9962260; -.
DR   KEGG; mfv:Mfer_0536; -.
DR   HOGENOM; CLU_048072_1_1_2; -.
DR   OMA; YRGATYW; -.
DR   OrthoDB; 36454at2157; -.
DR   Proteomes; UP000002315; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022791; L-PG_synthase/AglD.
DR   Pfam; PF03706; LPG_synthase_TM; 1.
DR   TIGRFAMs; TIGR00374; TIGR00374; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="UPF0104 membrane protein Mfer_0536"
FT                   /id="PRO_0000066217"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  38160 MW;  31161CB6D7033079 CRC64;
     MKHKKSIILI IISISLLGLM LIFIGPEKIV NDIRKADPLY LSLAVAVHML TLYLWMVRWR
     IAVVAAKIKT KNQPLFRILV LGLATNNITP AKSGGEALRA YLLSKYSKTP FESSFATVLI
     DKGLDTFPLI LLSIISLFHM ILVFRFSLWL VIGLLITLFA VVFSFFIILY VSVKPELGKK
     VKRGIMRIAR IFYKHKSKKL SKLESRISDA IVKYQDAVRL MIKNKNVIYV ALPLSFVIWF
     LEIIRIWAVF WAFGVYISPI IIAEVMIVAT LVSMVPIFPG GLGAIEGLMI LFYSMAGVPL
     PLSAAITIVE RLISFWLTIF LGVATLPYFG SDMVGKVFK