ID   Y538_STRP1              Reviewed;         399 AA.
AC   P66768; Q490A5; Q9A0Z8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Uncharacterized protein SPy_0538/M5005_Spy0445;
GN   Name=metK1; OrderedLocusNames=SPy_0538, M5005_Spy0445;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SIMILARITY: Belongs to the AdoMet synthetase 2 family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33533.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51063.1; -; Genomic_DNA.
DR   RefSeq; NP_268812.1; NC_002737.2.
DR   AlphaFoldDB; P66768; -.
DR   SMR; P66768; -.
DR   STRING; 1314.HKU360_00468; -.
DR   PaxDb; P66768; -.
DR   EnsemblBacteria; AAK33533; AAK33533; SPy_0538.
DR   KEGG; spy:SPy_0538; -.
DR   KEGG; spz:M5005_Spy0445; -.
DR   PATRIC; fig|160490.10.peg.460; -.
DR   HOGENOM; CLU_057642_0_0_9; -.
DR   OMA; IGHPDSI; -.
DR   Proteomes; UP000000750; Chromosome.
DR   Gene3D; 3.30.300.280; -; 1.
DR   Gene3D; 3.30.300.340; -; 1.
DR   InterPro; IPR042543; AdoMet_synthase_2.
DR   InterPro; IPR027790; AdoMet_synthase_2_family.
DR   InterPro; IPR042544; AdoMet_synthase_3.
DR   PANTHER; PTHR36697; PTHR36697; 1.
DR   Pfam; PF01941; AdoMet_Synthase; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..399
FT                   /note="Uncharacterized protein SPy_0538/M5005_Spy0445"
FT                   /id="PRO_0000150046"
SQ   SEQUENCE   399 AA;  45771 MW;  590FC44690960103 CRC64;
     MDLKITNGFY DPSHLSYEVV ERKGLGHPDT LADGIAEQIE IDYSLYCLDK FGVIPHHNFD
     KIIIRGGHSV QDFGGSDFIE PIKIIFLGRA SKKCFNSSIP LFKIQKKAAT KYLNRILPNL
     DVENYVEFET LTSDFTTKTN WFSPEAIEDL PEYLDVPKAN DTATMISYWP LTISEELALM
     IEGYFYKLDK NELPTPRFTK MGGDIKVMVV RNDLEYSIRI NFPLISKFFN NDIESQLYVD
     KHVEKIKKYI EQKYKNISFS IDYHYYLTTT GSCIDFGEEG AVGRGNKTHG IISSFRPNTM
     EAPAGKNCTY FVGKVWGFLS DTIAKEIYEA FNTPCQIIMQ LNIGSKLYRP THLFIQTEES
     VDQERVLEIV NRHLNNGKQN TNLILSTQHF IPKTNVYDG