ID   CASA1_BUBBU             Reviewed;         214 AA.
AC   O62823;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Alpha-S1-casein;
DE   Flags: Precursor;
GN   Name=CSN1S1;
OS   Bubalus bubalis (Domestic water buffalo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bubalus.
OX   NCBI_TaxID=89462;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Das P., Jain S., Garg L.C.;
RT   "cDNA cloning and sequencing of alpha S1-casein in Bubalus bubalis.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RA   Mishra B.P., Mukesh M., Kataria R.S., Ahlawat S.P.S.;
RT   "Sequence characterization of alpha S1 casein gene of Indian river
RT   buffalo.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; AJ005430; CAA06533.1; -; mRNA.
DR   EMBL; AY948385; AAX49507.1; -; mRNA.
DR   AlphaFoldDB; O62823; -.
DR   Allergome; 1259; Bub b 8.
DR   PRIDE; O62823; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026999; Alpha-s1_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR10240; PTHR10240; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Repeat; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..214
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000269038"
FT   REPEAT          85..99
FT   REPEAT          125..140
FT   MOD_RES         63
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         83
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
SQ   SEQUENCE   214 AA;  24327 MW;  AD837A5170156423 CRC64;
     MKLLILTCLV AVALARPKQP IKHQGLPQGV LNENLLRFFV APFPEVFGKE KVNELSTDIG
     SESTEDQAME DIKQMEAESI SSSEEIVPIS VEQKHIQKED VPSERYLGYL EQLLRLKKYN
     VPQLEIVPNL AEEQLHSMKE GIHAQQKEPM IGVNQELAYF YPQLFRQFYQ LDAYPSGAWY
     YVPLGTQYPD APSFSDIPNP IGSENSGKTT MPLW