CASA1_CAMDR
ID CASA1_CAMDR Reviewed; 230 AA.
AC O97943;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Alpha-S1-casein;
DE Flags: Precursor;
GN Name=CSN1S1;
OS Camelus dromedarius (Dromedary) (Arabian camel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=9838;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), PARTIAL PROTEIN SEQUENCE
RP (ISOFORMS LONG AND SHORT), PHOSPHORYLATION AT SER-33; SER-83; SER-85;
RP SER-86; SER-87 AND SER-88, AND MASS SPECTROMETRY.
RC STRAIN=Somali; TISSUE=Udder;
RX PubMed=9627840; DOI=10.1017/s0022029997002847;
RA Kappeler S., Farah Z., Puhan Z.;
RT "Sequence analysis of Camelus dromedarius milk caseins.";
RL J. Dairy Res. 65:209-222(1998).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=O97943-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=O97943-2; Sequence=VSP_028751;
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- MASS SPECTROMETRY: [Isoform Short]: Mass=24755; Method=MALDI; Note=with
CC 6 phosphate groups. The measured range is 16-222.;
CC Evidence={ECO:0000269|PubMed:9627840};
CC -!- MASS SPECTROMETRY: [Isoform Short]: Mass=24668; Method=MALDI; Note=The
CC measured range is 16-222.; Evidence={ECO:0000269|PubMed:9627840};
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; AJ012628; CAA10077.1; -; mRNA.
DR RefSeq; NP_001290495.1; NM_001303566.1. [O97943-2]
DR AlphaFoldDB; O97943; -.
DR iPTMnet; O97943; -.
DR GeneID; 105090954; -.
DR KEGG; cdk:105090954; -.
DR CTD; 1446; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR026999; Alpha-s1_casein.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR10240; PTHR10240; 1.
DR Pfam; PF00363; Casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Milk protein;
KW Phosphoprotein; Secreted; Signal.
FT SIGNAL 1..15
FT CHAIN 16..230
FT /note="Alpha-S1-casein"
FT /id="PRO_0000004447"
FT REGION 60..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 33
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT MOD_RES 86
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT MOD_RES 87
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0000305|PubMed:9627840"
FT VAR_SEQ 170..177
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:9627840"
FT /id="VSP_028751"
SQ SEQUENCE 230 AA; 26861 MW; 3A6BB3FC32BC6013 CRC64;
MKLLILTCLV AVALARPKYP LRYPEVFQNE PDSIEEVLNK RKILELAVVS PIQFRQENID
ELKDTRNEPT EDHIMEDTER KESGSSSSEE VVSSTTEQKD ILKEDMPSQR YLEELHRLNK
YKLLQLEAIR DQKLIPRVKL SSHPYLEQLY RINEDNHPQL GEPVKVVTQE QAYFHLEPFP
QFFQLGASPY VAWYYPPQVM QYIAHPSSYD TPEGIASEDG GKTDVMPQWW
