ID   CASA1_CAVPO             Reviewed;         198 AA.
AC   P04656;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Alpha-S1-casein;
DE   AltName: Full=Casein-B;
DE   Flags: Precursor;
GN   Name=CSN1S1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6548375; DOI=10.1042/bj2220561;
RA   Hall L., Laird J.E., Craig R.K.;
RT   "Nucleotide sequence determination of guinea-pig casein B mRNA reveals
RT   homology with bovine and rat alpha s1 caseins and conservation of the non-
RT   coding regions of the mRNA.";
RL   Biochem. J. 222:561-570(1984).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X00938; CAA25452.1; -; mRNA.
DR   PIR; S07130; S07130.
DR   AlphaFoldDB; P04656; -.
DR   InParanoid; P04656; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026999; Alpha-s1_casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR10240; PTHR10240; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..198
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000004449"
FT   REGION          28..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97943"
FT   MOD_RES         80
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P47710"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         83
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         84
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
SQ   SEQUENCE   198 AA;  23140 MW;  C63A72286A003EBF CRC64;
     MKLLILTCLV ASAVAMPKFP FRHTELFQTQ RGGSSSSSSS EERLKEENIF KFDQQKELQR
     KQSEKIKEII SESTEQREAS SISSSEEVVP KNTEQKHIPQ EDALYQQALE QLSRLIKYHQ
     LQMEVVHAQE QFHRINEHNQ AQVKEPMRVF NQLDAYPFAA WYYGPEVQYM SFLPFSSIPQ
     PIFPEDAQNT EVMPEWVM