ID   CASA1_EQUAS             Reviewed;         202 AA.
AC   P86272;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Alpha-S1-casein {ECO:0000303|PubMed:19862798};
GN   Name=CSN1S1 {ECO:0000250|UniProtKB:P47710};
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, VARIANT A1 GLN-88 DEL, VARIANT B
RP   34-HIS--GLU-38 DEL, AND VARIANTS B1 34-HIS--GLU-38 DEL AND GLN-88 DEL.
RC   STRAIN=Ragusana {ECO:0000269|PubMed:19862798};
RC   TISSUE=Milk {ECO:0000269|PubMed:19862798};
RX   PubMed=19862798; DOI=10.1002/jms.1683;
RA   Cunsolo V., Cairone E., Fontanini D., Criscione A., Muccilli V.,
RA   Saletti R., Foti S.;
RT   "Sequence determination of alphas1-casein isoforms from donkey by mass
RT   spectrometric methods.";
RL   J. Mass Spectrom. 44:1742-1753(2009).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC       {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=24406; Method=MALDI; Note=Variant A.;
CC       Evidence={ECO:0000269|PubMed:19862798};
CC   -!- MASS SPECTROMETRY: Mass=24278; Method=MALDI; Note=Variant A1.;
CC       Evidence={ECO:0000269|PubMed:19862798};
CC   -!- MASS SPECTROMETRY: Mass=23786; Method=MALDI; Note=Variant B.;
CC       Evidence={ECO:0000269|PubMed:19862798};
CC   -!- MASS SPECTROMETRY: Mass=23658; Method=MALDI; Note=Variant B1.;
CC       Evidence={ECO:0000269|PubMed:19862798};
CC   -!- MISCELLANEOUS: The sequence of variant A is shown.
CC       {ECO:0000269|PubMed:19862798}.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P86272; -.
DR   SMR; P86272; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026999; Alpha-s1_casein.
DR   InterPro; IPR001588; Casein.
DR   PANTHER; PTHR10240; PTHR10240; 1.
DR   Pfam; PF00363; Casein; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Milk protein; Phosphoprotein; Secreted.
FT   CHAIN           1..202
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000376022"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         18
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97943"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97943"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P47710"
FT   MOD_RES         74
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         76
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         77
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         78
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   VARIANT         34..38
FT                   /note="Missing (in B and B1)"
FT                   /evidence="ECO:0000269|PubMed:19862798"
FT   VARIANT         88
FT                   /note="Missing (in A1 and B1)"
FT                   /evidence="ECO:0000269|PubMed:19862798"
SQ   SEQUENCE   202 AA;  24406 MW;  10D081F2E0ADE929 CRC64;
     RPKLPHRHPE IIQNEQDSRE KVLKERKFPS FALHTPREEY INELNRQREL LKEKQKDEHK
     EYLIEDPEQQ ESSSTSSSEE VVPINTEQKR IPREDMLYQH TLEQLRRLSK YNQLQLQAIY
     AQEQLIRMKE NSQRKPMRVV NQEQAYFYLE PFQPSYQLDV YPYAAWFHPA QIMQHVAYSP
     FHDTAKLIAS ENSEKTDIIP EW