CASA1_MOUSE
ID CASA1_MOUSE Reviewed; 313 AA.
AC P19228;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Alpha-S1-casein;
DE Short=Alpha-casein;
DE Flags: Precursor;
GN Name=Csn1s1; Synonyms=Csn1, Csna;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2395885; DOI=10.1073/pnas.87.17.6897;
RA Grusby M.J., Mitchell S.C., Nabavi N., Glimcher L.H.;
RT "Casein expression in cytotoxic T lymphocytes.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6897-6901(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC phosphate.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR EMBL; M36780; AAA37142.1; -; mRNA.
DR EMBL; BC003859; AAH03859.1; -; mRNA.
DR CCDS; CCDS51534.1; -.
DR PIR; A36060; A36060.
DR RefSeq; NP_001272944.1; NM_001286015.1.
DR RefSeq; NP_001272945.1; NM_001286016.1.
DR RefSeq; NP_031810.1; NM_007784.3.
DR AlphaFoldDB; P19228; -.
DR IntAct; P19228; 2.
DR STRING; 10090.ENSMUSP00000092225; -.
DR PhosphoSitePlus; P19228; -.
DR CPTAC; non-CPTAC-4019; -.
DR PaxDb; P19228; -.
DR PeptideAtlas; P19228; -.
DR PRIDE; P19228; -.
DR Antibodypedia; 24253; 175 antibodies from 22 providers.
DR DNASU; 12990; -.
DR Ensembl; ENSMUST00000094641; ENSMUSP00000092225; ENSMUSG00000070702.
DR GeneID; 12990; -.
DR KEGG; mmu:12990; -.
DR UCSC; uc029vix.2; mouse.
DR CTD; 1446; -.
DR MGI; MGI:88540; Csn1s1.
DR VEuPathDB; HostDB:ENSMUSG00000070702; -.
DR eggNOG; ENOG502TEWT; Eukaryota.
DR GeneTree; ENSGT00390000017378; -.
DR InParanoid; P19228; -.
DR OMA; AFPLWAY; -.
DR OrthoDB; 1563397at2759; -.
DR TreeFam; TF340763; -.
DR Reactome; R-MMU-5223345; Miscellaneous transport and binding events.
DR BioGRID-ORCS; 12990; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Csn1s1; mouse.
DR PRO; PR:P19228; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P19228; protein.
DR Bgee; ENSMUSG00000070702; Expressed in thoracic mammary gland and 17 other tissues.
DR ExpressionAtlas; P19228; baseline and differential.
DR Genevisible; P19228; MM.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:1903496; P:response to 11-deoxycorticosterone; IBA:GO_Central.
DR GO; GO:1903494; P:response to dehydroepiandrosterone; IBA:GO_Central.
DR GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR GO; GO:0032570; P:response to progesterone; IBA:GO_Central.
DR InterPro; IPR026999; Alpha-s1_casein.
DR InterPro; IPR001588; Casein.
DR InterPro; IPR031305; Casein_CS.
DR PANTHER; PTHR10240; PTHR10240; 1.
DR Pfam; PF00363; Casein; 1.
DR PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE 2: Evidence at transcript level;
KW Milk protein; Phosphoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000250"
FT CHAIN 16..313
FT /note="Alpha-S1-casein"
FT /id="PRO_0000004457"
FT REPEAT 135..140
FT /note="1"
FT REPEAT 141..146
FT /note="2"
FT REPEAT 147..152
FT /note="3"
FT REPEAT 153..158
FT /note="4"
FT REPEAT 159..164
FT /note="5"
FT REPEAT 165..170
FT /note="6"
FT REPEAT 171..176
FT /note="7"
FT REPEAT 177..182
FT /note="8"
FT REPEAT 183..188
FT /note="9"
FT REPEAT 189..194
FT /note="10"
FT REPEAT 195..200
FT /note="11"
FT REPEAT 201..206
FT /note="12"
FT REPEAT 207..212
FT /note="13"
FT REPEAT 213..218
FT /note="14"
FT REPEAT 219..224
FT /note="15"
FT REGION 77..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..224
FT /note="15 X 6 AA tandem repeats"
FT COMPBIAS 83..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O97943"
FT MOD_RES 91
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P47710"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P18626"
FT MOD_RES 94
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P04653"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02662"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P04653"
SQ SEQUENCE 313 AA; 35602 MW; 7006C03C59409D70 CRC64;
MKLLILTCLV AAAFAMPRLH SRNAVSSQTQ QQHSSSEEIF KQPKYLNLNQ EFVNNMNRQR
ALLTEQNDEI KVTMDAASEE QAMASAQEDS SISSSSEESE EAIPNITEQK NIANEDMLNQ
CTLEQLQRQF KYNQLLQKAS LAKQASLFQQ PSLVQQASLF QQPSLLQQAS LFQQPSMAQQ
ASLLQQLLLA QQPSLALQVS PAQQSSLVQQ AFLAQQASLA QKHHPRLSQS YYPHMEQPYR
MNAYSQVQMR HPMSVVDQAL AQFSVQPFPQ IFQYDAFPLW AYFPQDMQYL TPKAVLNTFK
PIVSKDTEKT NVW
