ID   CASA1_NOTEU             Reviewed;         237 AA.
AC   P28549;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Alpha-S1-casein;
DE            Short=Alpha-casein;
DE   Flags: Precursor;
GN   Name=CSN1S1;
OS   Notamacropus eugenii (Tammar wallaby) (Macropus eugenii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Diprotodontia; Macropodidae; Notamacropus.
OX   NCBI_TaxID=9315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=1543530; DOI=10.1677/jme.0.0080013;
RA   Collet C., Joseph R., Nicholas K.R.;
RT   "Molecular characterization and in-vitro hormonal requirements for
RT   expression of two casein genes from a marsupial.";
RL   J. Mol. Endocrinol. 8:13-20(1992).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- INDUCTION: Maximal induction is dependent upon prolactin insulin and
CC       cortisol.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X54714; CAA38517.1; -; mRNA.
DR   PIR; S21356; S21356.
DR   AlphaFoldDB; P28549; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..237
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000004452"
FT   REGION          39..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P18626"
FT   MOD_RES         80
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
SQ   SEQUENCE   237 AA;  28123 MW;  310373F9DEA3F78D CRC64;
     MKLLIFSCLV TLALARPDAL RLSIDRHFKH RELENRLNED PIPVSEASSS EESVHQLNRD
     RRPLEKYELD KYREDLKTSS SEEFVTPSTN ERVRRQVEYN FNEEDSSASR ERKIEDFSEH
     DRQYLRRRVE ERALNLRYLE PLYYATEPEY YYYYAYVPVS SHDIPYQQKP LSLLPAKSHY
     LISTGLLNEP LPILRERLGR GFQSPSLLIL VLTENSNLFM GSVFYWCLQI AHPMQEI