ID   CASA1_PIG               Reviewed;         206 AA.
AC   P39035;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Alpha-S1-casein;
DE   Flags: Precursor;
GN   Name=CSN1S1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=1503265; DOI=10.1111/j.1365-2052.1992.tb00144.x;
RA   Alexander L.J., Beattie C.W.;
RT   "The sequence of porcine alpha s1-casein cDNA: evidence for protein
RT   variants generated by altered RNA splicing.";
RL   Anim. Genet. 23:283-288(1992).
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X54973; CAA38717.1; -; mRNA.
DR   PIR; A45661; A45661.
DR   RefSeq; NP_001004029.1; NM_001004029.2.
DR   AlphaFoldDB; P39035; -.
DR   PaxDb; P39035; -.
DR   PeptideAtlas; P39035; -.
DR   GeneID; 445514; -.
DR   KEGG; ssc:445514; -.
DR   CTD; 1446; -.
DR   eggNOG; ENOG502TEWT; Eukaryota.
DR   HOGENOM; CLU_126070_0_0_1; -.
DR   InParanoid; P39035; -.
DR   OMA; WYYPPQV; -.
DR   OrthoDB; 1478191at2759; -.
DR   TreeFam; TF340763; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; P39035; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:1903496; P:response to 11-deoxycorticosterone; IBA:GO_Central.
DR   GO; GO:1903494; P:response to dehydroepiandrosterone; IBA:GO_Central.
DR   GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR   GO; GO:0032570; P:response to progesterone; IBA:GO_Central.
DR   InterPro; IPR026999; Alpha-s1_casein.
DR   InterPro; IPR001588; Casein.
DR   PANTHER; PTHR10240; PTHR10240; 2.
DR   Pfam; PF00363; Casein; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..206
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000004453"
FT   REGION          67..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97943"
FT   MOD_RES         77
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P47710"
FT   MOD_RES         78
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         79
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P18626"
FT   MOD_RES         80
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         89
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
SQ   SEQUENCE   206 AA;  24148 MW;  58670C0B309A4456 CRC64;
     MKLLIFICLA AVALARPKPP LRHQEHLQNE PDSREELFKE RKFLRFPEVP LLSQFRQEII
     NELNRNHGME GHEQRGSSSS SSEEVVGNSA EQKHVQKEED VPSQSYLGHL QGLNKYKLRQ
     LEAIHDQELH RTNEDKHTQQ GEPMKGVNQE QAYFYFEPLH QFYQLDAYPY ATWYYPPQYI
     AHPLFTNIPQ PTAPEKGGKT EIMPQW