ID   CASA1_RABIT             Reviewed;         215 AA.
AC   P09115; Q53ZQ7;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Alpha-S1-casein;
DE            Short=Alpha-casein;
DE   Flags: Precursor;
GN   Name=CSN1S1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Mammary gland;
RX   PubMed=3211752; DOI=10.1093/nar/16.24.11813;
RA   Devinoy E., Schaerer E., Jolivet G., Fontaine M.-L., Kraehenbuhl J.-P.,
RA   Houdebine L.-M.;
RT   "Sequence of the rabbit alpha S1-casein cDNA.";
RL   Nucleic Acids Res. 16:11813-11813(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1572547; DOI=10.1016/0378-1119(92)90404-d;
RA   Jolivet G., Devinoy E., Fontaine M.-L., Houdebine L.-M.;
RT   "Structure of the gene encoding rabbit alpha s1-casein.";
RL   Gene 113:257-262(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Jolivet G., Devinoy E., Thepot D.;
RT   "5'upstream sequence of rabbit alpha s1-casein gene.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Important role in the capacity of milk to transport calcium
CC       phosphate.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
CC   -!- SIMILARITY: Belongs to the alpha-casein family. {ECO:0000305}.
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DR   EMBL; X13042; CAA31448.1; -; mRNA.
DR   EMBL; M77195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY284844; AAP37956.1; -; Genomic_DNA.
DR   PIR; JC1133; JC1133.
DR   RefSeq; NP_001075860.1; NM_001082391.1.
DR   AlphaFoldDB; P09115; -.
DR   STRING; 9986.ENSOCUP00000008181; -.
DR   Allergome; 2149; Ory c 8.
DR   GeneID; 100009257; -.
DR   KEGG; ocu:100009257; -.
DR   CTD; 1446; -.
DR   eggNOG; ENOG502TEWT; Eukaryota.
DR   HOGENOM; CLU_126070_0_0_1; -.
DR   InParanoid; P09115; -.
DR   OMA; WYYPPQV; -.
DR   OrthoDB; 1478191at2759; -.
DR   TreeFam; TF340763; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026999; Alpha-s1_casein.
DR   InterPro; IPR001588; Casein.
DR   InterPro; IPR031305; Casein_CS.
DR   PANTHER; PTHR10240; PTHR10240; 1.
DR   Pfam; PF00363; Casein; 1.
DR   PROSITE; PS00306; CASEIN_ALPHA_BETA; 1.
PE   2: Evidence at transcript level;
KW   Milk protein; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000250"
FT   CHAIN           16..215
FT                   /note="Alpha-S1-casein"
FT                   /id="PRO_0000004454"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O97943"
FT   MOD_RES         99
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P47710"
FT   MOD_RES         101
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P18626"
FT   MOD_RES         102
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         103
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
FT   MOD_RES         104
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04653"
FT   MOD_RES         111
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02662"
SQ   SEQUENCE   215 AA;  25528 MW;  40737A027636B255 CRC64;
     MKLLILTCLV ATALARHKFH LGHLKLTQEQ PESSEQEILK ERKLLRFVQT VPLELREEYV
     NELNRQRELL REKENEEIKG TRNEVTEEHV LADRETEASI SSSSEEIVPS STKQKYVPRE
     DLAYQPYVQQ QLLRMKERYQ IQEREPMRVV NQELAQLYLQ PFEQPYQLDA YLPAPWYYTP
     EVMQYVLSPL FYDLVTPSAF ESAEKTDVIP EWLKN