Y5516_ARATH
ID Y5516_ARATH Reviewed; 640 AA.
AC Q9FHK7; C0LGS6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Probable leucine-rich repeat receptor-like protein kinase At5g05160;
DE EC=2.7.11.-;
DE Flags: Precursor;
GN OrderedLocusNames=At5g05160; ORFNames=K2A11.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=20064227; DOI=10.1186/1471-2164-11-19;
RA Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.;
RT "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-
RT like protein kinase genes in Arabidopsis thaliana.";
RL BMC Genomics 11:19-19(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable leucine-rich repeat receptor-like protein kinase.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; FJ708769; ACN59361.1; -; mRNA.
DR EMBL; AB018111; BAB09692.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90835.1; -; Genomic_DNA.
DR RefSeq; NP_196135.1; NM_120598.4.
DR AlphaFoldDB; Q9FHK7; -.
DR SMR; Q9FHK7; -.
DR BioGRID; 15677; 2.
DR IntAct; Q9FHK7; 2.
DR STRING; 3702.AT5G05160.1; -.
DR iPTMnet; Q9FHK7; -.
DR PaxDb; Q9FHK7; -.
DR PRIDE; Q9FHK7; -.
DR ProteomicsDB; 243141; -.
DR EnsemblPlants; AT5G05160.1; AT5G05160.1; AT5G05160.
DR GeneID; 830398; -.
DR Gramene; AT5G05160.1; AT5G05160.1; AT5G05160.
DR KEGG; ath:AT5G05160; -.
DR Araport; AT5G05160; -.
DR TAIR; locus:2156784; AT5G05160.
DR eggNOG; ENOG502QT13; Eukaryota.
DR HOGENOM; CLU_000288_92_6_1; -.
DR InParanoid; Q9FHK7; -.
DR OMA; NWSESTP; -.
DR OrthoDB; 389502at2759; -.
DR PhylomeDB; Q9FHK7; -.
DR PRO; PR:Q9FHK7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHK7; baseline and differential.
DR Genevisible; Q9FHK7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:2000605; P:positive regulation of secondary growth; IMP:TAIR.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding;
KW Phosphoprotein; Receptor; Reference proteome; Repeat;
KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..640
FT /note="Probable leucine-rich repeat receptor-like protein
FT kinase At5g05160"
FT /id="PRO_0000324846"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 99..120
FT /note="LRR 1"
FT REPEAT 123..144
FT /note="LRR 2"
FT REPEAT 149..172
FT /note="LRR 3"
FT REPEAT 173..194
FT /note="LRR 4"
FT REPEAT 195..215
FT /note="LRR 5"
FT DOMAIN 347..619
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 299..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 469
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 353..361
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 375
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 370
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 427
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 445
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 498
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 503
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 514
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 518
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
SQ SEQUENCE 640 AA; 70564 MW; 0FA783835E8AECCA CRC64;
MNSSHTAFVA ASFFFLLLAA TAVLVSADLA SDEQALLNFA ASVPHPPKLN WNKNLSLCSS
WIGITCDESN PTSRVVAVRL PGVGLYGSIP PATLGKLDAL KVLSLRSNSL FGTLPSDILS
LPSLEYLYLQ HNNFSGELTT NSLPSISKQL VVLDLSYNSL SGNIPSGLRN LSQITVLYLQ
NNSFDGPIDS LDLPSVKVVN LSYNNLSGPI PEHLKKSPEY SFIGNSLLCG PPLNACSGGA
ISPSSNLPRP LTENLHPVRR RQSKAYIIAI VVGCSVAVLF LGIVFLVCLV KKTKKEEGGG
EGVRTQMGGV NSKKPQDFGS GVQDPEKNKL FFFERCNHNF DLEDLLKASA EVLGKGSFGT
AYKAVLEDTT AVVVKRLREV VASKKEFEQQ MEIVGKINQH SNFVPLLAYY YSKDEKLLVY
KYMTKGSLFG IMHGNRGDRG VDWETRMKIA TGTSKAISYL HSLKFVHGDI KSSNILLTED
LEPCLSDTSL VTLFNLPTHT PRTIGYNAPE VIETRRVSQR SDVYSFGVVI LEMLTGKTPL
TQPGLEDERV VIDLPRWVRS VVREEWTAEV FDVELLKFQN IEEEMVQMLQ LALACVARNP
ESRPKMEEVA RMIEDVRRLD QSQQLQQNRT SSEATSNVSE
